ELAVL1
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ELAV like RNA binding protein 1 | MIM:603466 | Ensembl:ENSG00000066044 | HGNC:HGNC:3312 | PA27740 | 19p13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ELAVL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0010494 | cytoplasmic stress granule |
| CC | HDA | GO:0016020 | membrane |
| CC | ISS | GO:1990904 | ribonucleoprotein complex |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IDA | GO:0045727 | positive regulation of translation |
| BP | IDA | GO:0048255 | mRNA stabilization |
| BP | IMP | GO:0048255 | mRNA stabilization |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IGI | GO:0060965 | negative regulation of gene silencing by miRNA |
| BP | IMP | GO:0060965 | negative regulation of gene silencing by miRNA |
| BP | IDA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IMP | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | ISS | GO:2000036 | regulation of stem cell population maintenance |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | TAS | GO:0003729 | mRNA binding |
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
| MF | ISS | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017091 | AU-rich element binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0035198 | miRNA binding |
| MF | IDA | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: ELAVL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ELAVL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| netpath | Pathway_Gastrin | Gastrin |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD255 | SB225002 | 7 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ELAVL1
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