MYO18B
Summary: The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin XVIIIB | MIM:607295 | Ensembl:ENSG00000133454 | HGNC:HGNC:18150 | PA38300 | 22q12.1 |
GO terms in MYO18B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007018 | microtubule-based movement |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0016461 | unconventional myosin complex |
| CC | IEA | GO:0030017 | sarcomere |
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | IEA | GO:0003779 | actin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
Gene expression in normal tissue: MYO18B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO18B
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD79 | Gemcitabine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO18B
CLASSFICATION
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