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COL14A1

Summary: This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecollagen type XIV alpha 1 chain OMIM IDMIM:120324 Ensembl IDEnsembl:ENSG00000187955 HGNC IDHGNC:HGNC:2191 PHARMGKB IDPA26707 Map Location8q24.12

Gene Categories:

DRUGGABLE GENOME

GO terms in COL14A1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0003429	growth plate cartilage chondrocyte morphogenesis
BP	NAS	GO:0030198	extracellular matrix organization
BP	NAS	GO:0030199	collagen fibril organization
BP	NAS	GO:0098609	cell-cell adhesion
CC	HDA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region

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Gene expression in normal tissue: COL14A1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COL14A1

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Database	Pathway ID	Pathway Des.
kegg	hsa04974	Protein digestion and absorption - Homo sapiens (human)
reactome	R-HSA-1442490	Collagen degradation
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474290	Collagen formation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD147	Prima-1	2
iGMDRD552	AZD-1775	6
iGMDRD505	Pevonedistat	1
iGMDRD882	CIL41	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL14A1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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