XPO5
Summary: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| exportin 5 | MIM:607845 | Ensembl:ENSG00000124571 | HGNC:HGNC:17675 | PA134979214 | 6p21.1 |
Gene Categories:
TRANSPORTERGO terms in XPO5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000049 | tRNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003723 | RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0005049 | nuclear export signal receptor activity |
| MF | IMP | GO:0005049 | nuclear export signal receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008536 | Ran GTPase binding |
| MF | IPI | GO:0008536 | Ran GTPase binding |
| MF | IEA | GO:0008565 | protein transporter activity |
| MF | IDA | GO:0070883 | pre-miRNA binding |
| MF | IDA | GO:0070883 | pre-miRNA binding |
| MF | NAS | GO:0070883 | pre-miRNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | IDA | GO:0042272 | nuclear RNA export factor complex |
| CC | IBA | GO:0042565 | RNA nuclear export complex |
| CC | IDA | GO:0042565 | RNA nuclear export complex |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | IDA | GO:0006611 | protein export from nucleus |
| BP | TAS | GO:0010586 | miRNA metabolic process |
| BP | IDA | GO:0035281 | pre-miRNA export from nucleus |
| BP | IMP | GO:0035281 | pre-miRNA export from nucleus |
| BP | NAS | GO:0035281 | pre-miRNA export from nucleus |
| BP | IBA | GO:0046825 | regulation of protein export from nucleus |
| BP | IDA | GO:1900370 | positive regulation of RNA interference |
Gene expression in normal tissue: XPO5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XPO5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-203927 | MicroRNA (miRNA) biogenesis |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| wikipathways | WP2338 | miRNA Biogenesis |
| wikipathways | WP2805 | RNA interference |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD679 | Bistramide A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XPO5
CLASSFICATION
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