DBN1
Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namedrebrin 1 OMIM IDMIM:126660 Ensembl IDEnsembl:ENSG00000113758 HGNC IDHGNC:HGNC:2695 PHARMGKB IDPA27163 Map Location5q35.3 | |||||
GO terms in DBN1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005522 | profilin binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | ISS | GO:0007015 | actin filament organization |
| BP | IEA | GO:0010643 | cell communication by chemical coupling |
Gene expression in normal tissue: DBN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DBN1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DBN1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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