DBN1
Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| drebrin 1 | MIM:126660 | Ensembl:ENSG00000113758 | HGNC:HGNC:2695 | PA27163 | 5q35.3 |
GO terms in DBN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005522 | profilin binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | ISS | GO:0007015 | actin filament organization |
| BP | IEA | GO:0010643 | cell communication by chemical coupling |
| BP | IEA | GO:0010644 | cell communication by electrical coupling |
| BP | IEA | GO:0032507 | maintenance of protein location in cell |
| BP | NAS | GO:0048168 | regulation of neuronal synaptic plasticity |
| BP | NAS | GO:0050773 | regulation of dendrite development |
| BP | IEA | GO:0061351 | neural precursor cell proliferation |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005921 | gap junction |
| CC | ISS | GO:0015629 | actin cytoskeleton |
| CC | NAS | GO:0030425 | dendrite |
| CC | ISS | GO:0030426 | growth cone |
| CC | TAS | GO:0030863 | cortical cytoskeleton |
| CC | NAS | GO:0042641 | actomyosin |
Gene expression in normal tissue: DBN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DBN1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD154 | NSC23766 | 7 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD329 | Merck60 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DBN1
CLASSFICATION
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