NFKB2

Summary: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear factor kappa B subunit 2
OMIM IDMIM:164012
Ensembl IDEnsembl:ENSG00000077150
HGNC IDHGNC:HGNC:7795
PHARMGKB IDPA31600
Map Location10q24.32

Gene Categories:

DRUGGABLE GENOME

GO terms in NFKB2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0033257 Bcl3/NF-kappaB2 complex
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Gene expression in normal tissue: NFKB2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 12

Gene-drug pathway distribution

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Pathways in NFKB2


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Database
Pathway ID
Pathway Des.
pharmgkb PA162356267 EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkb PA165985892 Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pid il12_2pathway IL12-mediated signaling events
pid nfkappabalternativepathway Alternative NF-kappaB pathway
netpath Pathway_RANKL RANKL
netpath Pathway_TNFalpha TNFalpha
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 6
iGMDRD297 Austocystin D 3
iGMDRD698 Neratinib 6
iGMDRD562 Navitoclax 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFKB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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