NFKB2
Summary: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor kappa B subunit 2 | MIM:164012 | Ensembl:ENSG00000077150 | HGNC:HGNC:7795 | PA31600 | 10q24.32 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NFKB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0033257 | Bcl3/NF-kappaB2 complex |
| BP | IEA | GO:0002268 | follicular dendritic cell differentiation |
| BP | IEA | GO:0002467 | germinal center formation |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IEA | GO:0048536 | spleen development |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: NFKB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFKB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | nfkappabalternativepathway | Alternative NF-kappaB pathway |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| netpath | Pathway_TWEAK | TWEAK |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3926 | ApoE and miR-146 in inflammation and atherosclerosis |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448706 | Interleukin-1 processing |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-4755510 | SUMOylation of immune response proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5603029 | IkBA variant leads to EDA-ID |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-844456 | The NLRP3 inflammasome |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD219 | Bax channel blocker | 6 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFKB2
CLASSFICATION
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