TRPS1
Summary: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcriptional repressor GATA binding 1 | MIM:604386 | Ensembl:ENSG00000104447 | HGNC:HGNC:12340 | PA37013 | 8q23.3 |
GO terms in TRPS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | ISS | GO:0032330 | regulation of chondrocyte differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0051291 | protein heterooligomerization |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: TRPS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPS1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 5 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD152 | 179324-69-7 | 9 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD497 | 16beta-Bromoandrosterone | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD116 | CD437 | 7 |
| iGMDRD698 | Neratinib | 9 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPS1
CLASSFICATION
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