TRPS1


Summary: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transcriptional repressor GATA binding 1MIM:604386Ensembl:ENSG00000104447HGNC:HGNC:12340PA370138q23.3

GO terms in TRPS1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019904protein domain specific binding
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0001501skeletal system development
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006607NLS-bearing protein import into nucleus
BPISSGO:0032330regulation of chondrocyte differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0051291protein heterooligomerization
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIMPGO:0032991protein-containing complex

Gene expression in normal tissue: TRPS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRPS1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250025
iGMDRD187BRD98763
iGMDRD870BRD636103
iGMDRD318PAC-13
iGMDRD398Sepantronium4
iGMDRD562Navitoclax2
iGMDRD577BIX012942
iGMDRD100Zebularine2
iGMDRD23Gossypol3
iGMDRD1008SR-II-138A3
iGMDRD420Leucascandrolide A3
iGMDRD889Compound 7d-cis5
iGMDRD126Tipifarnib8
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide4
iGMDRD670ML 2103
iGMDRD152179324-69-79
iGMDRD202Curcumin2
iGMDRD121GMX17782
iGMDRD103SN-383
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide5
iGMDRD366PI-1033
iGMDRD872BRD71375
iGMDRD414MST-3122
iGMDRD286Nsc 6328393
iGMDRD871BRD63682
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 34
iGMDRD486Tosedostat3
iGMDRD84Lovastatin acid3
iGMDRD49716beta-Bromoandrosterone1
iGMDRD424Tamatinib2
iGMDRD116CD4377
iGMDRD698Neratinib9
iGMDRD123Isoevodiamine3
iGMDRD211(1S,3R)-RSL31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRPS1

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