TRPS1

Summary: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranscriptional repressor GATA binding 1
OMIM IDMIM:604386
Ensembl IDEnsembl:ENSG00000104447
HGNC IDHGNC:HGNC:12340
PHARMGKB IDPA37013
Map Location8q23.3

GO terms in TRPS1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IC GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF TAS GO:0003700 DNA-binding transcription factor activity
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Gene expression in normal tissue: TRPS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined27Apoptosis regulation3PI3K/MTOR signaling1Ferroptosis1DNA replication1Proteasome1Biosynthesis of secondary metabolites1Longevity regulating pathway1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in TRPS1


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 5
iGMDRD187 BRD9876 3
iGMDRD870 BRD63610 3
iGMDRD318 PAC-1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRPS1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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