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MAP3K5

Summary: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
mitogen-activated protein kinase kinase kinase 5	MIM:602448	Ensembl:ENSG00000197442	HGNC:HGNC:6857	PA30601	6q23.3

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE SERINE THREONINE KINASE PROTEASE KINASE CELL SURFACE DRUGGABLE GENOME

GO terms in MAP3K5

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000165	MAPK cascade
BP	IBA	GO:0000186	activation of MAPKK activity
BP	IDA	GO:0000186	activation of MAPKK activity
BP	IEA	GO:0002931	response to ischemia
BP	IDA	GO:0006468	protein phosphorylation
BP	IDA	GO:0007254	JNK cascade
BP	TAS	GO:0007257	activation of JUN kinase activity
BP	IBA	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
BP	IDA	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
BP	IEA	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
BP	IEA	GO:0016032	viral process
BP	IDA	GO:0034198	cellular response to amino acid starvation
BP	IMP	GO:0034976	response to endoplasmic reticulum stress
BP	IEA	GO:0038066	p38MAPK cascade
BP	IEA	GO:0042060	wound healing
BP	IDA	GO:0043065	positive regulation of apoptotic process
BP	IDA	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IMP	GO:0043507	positive regulation of JUN kinase activity
BP	IEA	GO:0045087	innate immune response
BP	IEA	GO:0045663	positive regulation of myoblast differentiation
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	ISS	GO:0046330	positive regulation of JNK cascade
BP	IDA	GO:0051403	stress-activated MAPK cascade
BP	ISS	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BP	IDA	GO:0070301	cellular response to hydrogen peroxide
BP	IEA	GO:0071356	cellular response to tumor necrosis factor
BP	IEA	GO:0072577	endothelial cell apoptotic process
BP	TAS	GO:0097190	apoptotic signaling pathway
BP	IEA	GO:0097300	programmed necrotic cell death
BP	IEA	GO:1900745	positive regulation of p38MAPK cascade
BP	IGI	GO:1901216	positive regulation of neuron death
BP	ISS	GO:1901216	positive regulation of neuron death
BP	IEA	GO:1902170	cellular response to reactive nitrogen species
BP	IEA	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0009897	external side of plasma membrane
CC	IMP	GO:0032991	protein-containing complex
CC	IDA	GO:1902911	protein kinase complex
CC	IDA	GO:1990604	IRE1-TRAF2-ASK1 complex
MF	IDA	GO:0000287	magnesium ion binding
MF	IBA	GO:0004672	protein kinase activity
MF	IDA	GO:0004672	protein kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IDA	GO:0004709	MAP kinase kinase kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	IEA	GO:0019901	protein kinase binding
MF	IPI	GO:0019903	protein phosphatase binding
MF	IPI	GO:0019904	protein domain specific binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0042803	protein homodimerization activity

Gene expression in normal tissue: MAP3K5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K5

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2559580	Oxidative Stress Induced Senescence
reactome	R-HSA-2559580	Oxidative Stress Induced Senescence
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-8953897	Cellular responses to external stimuli
biocarta	41bbpathway	the 41bb-dependent immune response
biocarta	hivnefpathway	hiv-1 nef: negative effector of fas and tnf
biocarta	il10pathway	il-10 anti-inflammatory signaling pathway
biocarta	keratinocytepathway	keratinocyte differentiation
biocarta	mapkpathway	mapkinase signaling pathway
biocarta	p38mapkpathway	p38 mapk signaling pathway
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04141	Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa04668	TNF signaling pathway - Homo sapiens (human)
kegg	hsa04714	Thermogenesis - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa05014	Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)
pid	hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
pid	p38_mkk3_6pathway	p38 MAPK signaling pathway
pid	pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pid	tnfpathway	TNF receptor signaling pathway
netpath	Pathway_TNFalpha	TNFalpha
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP1971	Integrated Cancer Pathway
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP2447	Amyotrophic lateral sclerosis (ALS)
wikipathways	WP3611	Photodynamic therapy-induced AP-1 survival signaling.
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3878	ATM Signaling Network in Development and Disease
wikipathways	WP3879	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP400	p38 MAPK Signaling Pathway
wikipathways	WP481	Insulin Signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD237	ABT-751	2
iGMDRD351	GW843682X	3
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD154	NSC23766	5
iGMDRD945	ML214	1
iGMDRD177	Teniposide	3
iGMDRD123	Isoevodiamine	2
iGMDRD901	ELCPK	2
iGMDRD512	nutlin 3	5
iGMDRD307	Manumycin A	3
iGMDRD424	Tamatinib	3
iGMDRD269	Purmorphamine	2
iGMDRD82	Quiflapon	3
iGMDRD300	Tozasertib	2
iGMDRD158	NSC141540	5
iGMDRD137	Indisulam	3
iGMDRD103	SN-38	3
iGMDRD267	Oligomycin A	3
iGMDRD705	Nakiterpiosin	3
iGMDRD105	Triptolide	2
iGMDRD61	Kinetin riboside	1
iGMDRD201	SKI II	3
iGMDRD446	LY 2183240	2
iGMDRD297	Austocystin D	1
iGMDRD420	Leucascandrolide A	3
iGMDRD579	PF750	2
iGMDRD889	Compound 7d-cis	3
iGMDRD126	Tipifarnib	3
iGMDRD546	BMS-754807	2
iGMDRD780	PP-30	3
iGMDRD506	Fedratinib	3
iGMDRD100	Zebularine	2
iGMDRD524	ISX-9	3
iGMDRD356	PNU-74654	1
iGMDRD802	4-methylfasudil	2
iGMDRD255	SB225002	3
iGMDRD187	BRD9876	2
iGMDRD870	BRD63610	3
iGMDRD294	Batimastat	1
iGMDRD782	DC-45-A2	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K5

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DATATYPES

CLASSFICATION

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