CTSV
Summary: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cathepsin V | MIM:603308 | Ensembl:ENSG00000136943 | HGNC:HGNC:2538 | PA27036 | 9q22.33 |
GO terms in CTSV
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004177 | aminopeptidase activity |
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008234 | cysteine-type peptidase activity |
| MF | IEA | GO:0016807 | cysteine-type carboxypeptidase activity |
| MF | IEA | GO:0030984 | kininogen binding |
| MF | IEA | GO:0042277 | peptide binding |
| MF | IEA | GO:0042393 | histone binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005764 | lysosome |
| CC | IEA | GO:0005902 | microvillus |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0030141 | secretory granule |
| CC | IEA | GO:0043005 | neuron projection |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0045177 | apical part of cell |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0009267 | cellular response to starvation |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0010259 | multicellular organism aging |
| BP | IEA | GO:0010839 | negative regulation of keratinocyte proliferation |
| BP | IEA | GO:0016540 | protein autoprocessing |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | IEA | GO:0021675 | nerve development |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IEA | GO:0031069 | hair follicle morphogenesis |
| BP | IEA | GO:0034698 | response to gonadotropin |
| BP | TAS | GO:0045616 | regulation of keratinocyte differentiation |
| BP | IEA | GO:0046697 | decidualization |
| BP | IEA | GO:0048102 | autophagic cell death |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IBA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IEA | GO:0060008 | Sertoli cell differentiation |
| BP | IEA | GO:1990834 | response to odorant |
| BP | IEA | GO:2000249 | regulation of actin cytoskeleton reorganization |
Gene expression in normal tissue: CTSV
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTSV
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| wikipathways | WP474 | Endochondral Ossification |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236977 | Endosomal/Vacuolar pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD329 | Merck60 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTSV
CLASSFICATION
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