CTSV

Summary: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecathepsin V
OMIM IDMIM:603308
Ensembl IDEnsembl:ENSG00000136943
HGNC IDHGNC:HGNC:2538
PHARMGKB IDPA27036
Map Location9q22.33

GO terms in CTSV


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004177 aminopeptidase activity
MF IBA GO:0004197 cysteine-type endopeptidase activity
MF TAS GO:0004197 cysteine-type endopeptidase activity
MF TAS GO:0004252 serine-type endopeptidase activity
MF IPI GO:0005515 protein binding
MF TAS GO:0008234 cysteine-type peptidase activity
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Gene expression in normal tissue: CTSV

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 18

Gene-drug pathway distribution

Pathways in CTSV


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Database
Pathway ID
Pathway Des.
kegg hsa04142 Lysosome - Homo sapiens (human)
kegg hsa04210 Apoptosis - Homo sapiens (human)
wikipathways WP474 Endochondral Ossification
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236977 Endosomal/Vacuolar pathway
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD151 CHM-1 6
iGMDRD420 Leucascandrolide A 3
iGMDRD280 CYTOCHALASIN B 2
iGMDRD123 Isoevodiamine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTSV

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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