PPARD
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600409 Ensembl IDEnsembl:ENSG00000112033 HGNC IDHGNC:HGNC:9235 PHARMGKB IDPA33557 Map Location6p21.31 | |||||
GO terms in PPARD
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006029 | proteoglycan metabolic process |
| BP | TAS | GO:0006091 | generation of precursor metabolites and energy |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: PPARD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPARD
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPARD
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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