PPARD
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| peroxisome proliferator activated receptor delta | MIM:600409 | Ensembl:ENSG00000112033 | HGNC:HGNC:9235 | PA33557 | 6p21.31 |
GO terms in PPARD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006029 | proteoglycan metabolic process |
| BP | TAS | GO:0006091 | generation of precursor metabolites and energy |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | ISS | GO:0006629 | lipid metabolic process |
| BP | IBA | GO:0006631 | fatty acid metabolic process |
| BP | ISS | GO:0006635 | fatty acid beta-oxidation |
| BP | TAS | GO:0006635 | fatty acid beta-oxidation |
| BP | IEA | GO:0006776 | vitamin A metabolic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007507 | heart development |
| BP | TAS | GO:0007566 | embryo implantation |
| BP | TAS | GO:0008203 | cholesterol metabolic process |
| BP | ISS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | ISS | GO:0008366 | axon ensheathment |
| BP | IEA | GO:0008654 | phospholipid biosynthetic process |
| BP | TAS | GO:0009062 | fatty acid catabolic process |
| BP | IEA | GO:0009299 | mRNA transcription |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
| BP | IBA | GO:0010887 | negative regulation of cholesterol storage |
| BP | IEA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0014842 | regulation of skeletal muscle satellite cell proliferation |
| BP | IEA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | ISS | GO:0015908 | fatty acid transport |
| BP | IBA | GO:0019216 | regulation of lipid metabolic process |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | IEA | GO:0031589 | cell-substrate adhesion |
| BP | IBA | GO:0031667 | response to nutrient levels |
| BP | IEA | GO:0032024 | positive regulation of insulin secretion |
| BP | IEA | GO:0032966 | negative regulation of collagen biosynthetic process |
| BP | IEA | GO:0033189 | response to vitamin A |
| BP | IBA | GO:0033993 | response to lipid |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0043415 | positive regulation of skeletal muscle tissue regeneration |
| BP | IEA | GO:0043616 | keratinocyte proliferation |
| BP | NAS | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IEA | GO:0045662 | negative regulation of myoblast differentiation |
| BP | IEA | GO:0045684 | positive regulation of epidermis development |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045923 | positive regulation of fatty acid metabolic process |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0046697 | decidualization |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IBA | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0051546 | keratinocyte migration |
| BP | IEA | GO:0060612 | adipose tissue development |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:0071396 | cellular response to lipid |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:0097190 | apoptotic signaling pathway |
| BP | IEA | GO:0097755 | positive regulation of blood vessel diameter |
| BP | ISS | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | NAS | GO:1904659 | glucose transmembrane transport |
| BP | IEA | GO:2000288 | positive regulation of myoblast proliferation |
| CC | ISS | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IBA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IBA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IEA | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0004879 | nuclear receptor activity |
| MF | IDA | GO:0004879 | nuclear receptor activity |
| MF | IBA | GO:0005504 | fatty acid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0008144 | drug binding |
| MF | IDA | GO:0008144 | drug binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0008289 | lipid binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0051059 | NF-kappaB binding |
| MF | IDA | GO:0070539 | linoleic acid binding |
| MF | IBA | GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Gene expression in normal tissue: PPARD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPARD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4030 | SCFA and skeletal muscle substrate metabolism |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| biocarta | pparpathway | basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD210 | AC55649 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD577 | BIX01294 | 10 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPARD
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.