PPARD


Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
peroxisome proliferator activated receptor deltaMIM:600409Ensembl:ENSG00000112033HGNC:HGNC:9235PA335576p21.31

GO terms in PPARD


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPNASGO:0006006glucose metabolic process
BPIEAGO:0006029proteoglycan metabolic process
BPTASGO:0006091generation of precursor metabolites and energy
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPISSGO:0006629lipid metabolic process
BPIBAGO:0006631fatty acid metabolic process
BPISSGO:0006635fatty acid beta-oxidation
BPTASGO:0006635fatty acid beta-oxidation
BPIEAGO:0006776vitamin A metabolic process
BPIMPGO:0006915apoptotic process
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007507heart development
BPTASGO:0007566embryo implantation
BPTASGO:0008203cholesterol metabolic process
BPISSGO:0008283cell proliferation
BPTASGO:0008283cell proliferation
BPISSGO:0008366axon ensheathment
BPIEAGO:0008654phospholipid biosynthetic process
BPTASGO:0009062fatty acid catabolic process
BPIEAGO:0009299mRNA transcription
BPIEAGO:0009749response to glucose
BPIBAGO:0009755hormone-mediated signaling pathway
BPIBAGO:0010887negative regulation of cholesterol storage
BPIEAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0014823response to activity
BPIEAGO:0014842regulation of skeletal muscle satellite cell proliferation
BPIEAGO:0014912negative regulation of smooth muscle cell migration
BPISSGO:0015908fatty acid transport
BPIBAGO:0019216regulation of lipid metabolic process
BPIBAGO:0030154cell differentiation
BPIEAGO:0030154cell differentiation
BPIEAGO:0030308negative regulation of cell growth
BPIEAGO:0030522intracellular receptor signaling pathway
BPIEAGO:0031589cell-substrate adhesion
BPIBAGO:0031667response to nutrient levels
BPIEAGO:0032024positive regulation of insulin secretion
BPIEAGO:0032966negative regulation of collagen biosynthetic process
BPIEAGO:0033189response to vitamin A
BPIBAGO:0033993response to lipid
BPIEAGO:0042060wound healing
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIEAGO:0043415positive regulation of skeletal muscle tissue regeneration
BPIEAGO:0043616keratinocyte proliferation
BPNASGO:0045600positive regulation of fat cell differentiation
BPIEAGO:0045662negative regulation of myoblast differentiation
BPIEAGO:0045684positive regulation of epidermis development
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045923positive regulation of fatty acid metabolic process
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0046697decidualization
BPIEAGO:0048662negative regulation of smooth muscle cell proliferation
BPIEAGO:0050680negative regulation of epithelial cell proliferation
BPIBAGO:0050728negative regulation of inflammatory response
BPIEAGO:0050728negative regulation of inflammatory response
BPIEAGO:0051546keratinocyte migration
BPIEAGO:0060612adipose tissue development
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIBAGO:0071396cellular response to lipid
BPIEAGO:0071456cellular response to hypoxia
BPIMPGO:0097190apoptotic signaling pathway
BPIEAGO:0097755positive regulation of blood vessel diameter
BPISSGO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II
BPNASGO:1904659glucose transmembrane transport
BPIEAGO:2000288positive regulation of myoblast proliferation
CCISSGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0090575RNA polymerase II transcription factor complex
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001103RNA polymerase II repressing transcription factor binding
MFIBAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFISSGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFISSGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFNASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFIEAGO:0003713transcription coactivator activity
MFIBAGO:0004879nuclear receptor activity
MFIDAGO:0004879nuclear receptor activity
MFIBAGO:0005504fatty acid binding
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0008144drug binding
MFIDAGO:0008144drug binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0008289lipid binding
MFIDAGO:0008289lipid binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIEAGO:0043565sequence-specific DNA binding
MFIEAGO:0046982protein heterodimerization activity
MFIEAGO:0051059NF-kappaB binding
MFIDAGO:0070539linoleic acid binding
MFIBAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding

Gene expression in normal tissue: PPARD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPARD


DatabasePathway IDPathway Des.
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP236Adipogenesis
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4030SCFA and skeletal muscle substrate metabolism
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrix
reactomeR-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-70268Pyruvate metabolism
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8978868Fatty acid metabolism
reactomeR-HSA-9006931Signaling by Nuclear Receptors
biocartapparpathwaybasic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
biocartawntpathwaywnt signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside1
iGMDRD341Triacsin c5
iGMDRD634SCHEMBL26080412
iGMDRD466Chaetocin3
iGMDRD123Isoevodiamine3
iGMDRD679Bistramide A3
iGMDRD420Leucascandrolide A3
iGMDRD248BRD43541
iGMDRD210AC556492
iGMDRD79Gemcitabine1
iGMDRD424Tamatinib3
iGMDRD780PP-304
iGMDRD269Purmorphamine3
iGMDRD577BIX0129410
iGMDRD872BRD71374
iGMDRD100Zebularine3
iGMDRD23Gossypol3
iGMDRD246NPC262
iGMDRD267Oligomycin A1
iGMDRD231Importazole3
iGMDRD52Rotenone2
iGMDRD705Nakiterpiosin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPARD

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