FZD1

Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namefrizzled class receptor 1
OMIM IDMIM:603408
Ensembl IDEnsembl:ENSG00000157240
HGNC IDHGNC:HGNC:4038
PHARMGKB IDPA28455
Map Location7q21.13

GO terms in FZD1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005102 signaling receptor binding
MF IPI GO:0005109 frizzled binding
MF IPI GO:0005515 protein binding
MF IBA GO:0017147 Wnt-protein binding
MF IPI GO:0017147 Wnt-protein binding
MF NAS GO:0017147 Wnt-protein binding
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Gene expression in normal tissue: FZD1

Gene-model tissue-cancer distribution: Bubble Plot

UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 8undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 26BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 12BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3

Gene-drug pathway distribution

undefined14PI3K/MTOR signaling2Cell cycle1ERK MAPK signaling1DNA replication1

Pathways in FZD1


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Database
Pathway ID
Pathway Des.
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP236 Adipogenesis
wikipathways WP2804 Hair Follicle Development- Induction (Part 1 of 3)
wikipathways WP3664 Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathways WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathways WP3931 ESC Pluripotency Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD366 PI-103 2
iGMDRD100 Zebularine 6
iGMDRD399 Selumetinib 1
iGMDRD356 PNU-74654 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FZD1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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