FZD1
Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| frizzled class receptor 1 | MIM:603408 | Ensembl:ENSG00000157240 | HGNC:HGNC:4038 | PA28455 | 7q21.13 |
GO terms in FZD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IPI | GO:0017147 | Wnt-protein binding |
| MF | NAS | GO:0017147 | Wnt-protein binding |
| MF | IPI | GO:0030165 | PDZ domain binding |
| MF | IBA | GO:0042813 | Wnt-activated receptor activity |
| MF | IDA | GO:0042813 | Wnt-activated receptor activity |
| MF | NAS | GO:0042813 | Wnt-activated receptor activity |
| MF | TAS | GO:0042813 | Wnt-activated receptor activity |
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0003149 | membranous septum morphogenesis |
| BP | IEA | GO:0003150 | muscular septum morphogenesis |
| BP | IEA | GO:0003151 | outflow tract morphogenesis |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007267 | cell-cell signaling |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IEA | GO:0030855 | epithelial cell differentiation |
| BP | IDA | GO:0035425 | autocrine signaling |
| BP | IBA | GO:0035567 | non-canonical Wnt signaling pathway |
| BP | IMP | GO:0042493 | response to drug |
| BP | IMP | GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| BP | IMP | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0060022 | hard palate development |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IGI | GO:0060070 | canonical Wnt signaling pathway |
| BP | NAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| BP | TAS | GO:0099054 | presynapse assembly |
| BP | IEA | GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
| BP | NAS | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IC | GO:1990909 | Wnt signalosome |
Gene expression in normal tissue: FZD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FZD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP3664 | Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_signaling_pathway | Wnt signaling network |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntlrp6pathway | wnt lrp6 signalling |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4608870 | Asymmetric localization of PCP proteins |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 2 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FZD1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.