Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008].

frizzled class receptor 1MIM:603408Ensembl:ENSG00000157240HGNC:HGNC:4038PA284557q21.13

GO terms in FZD1

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005109frizzled binding
MFIPIGO:0005515protein binding
MFIBAGO:0017147Wnt-protein binding
MFIPIGO:0017147Wnt-protein binding
MFNASGO:0017147Wnt-protein binding
MFIPIGO:0030165PDZ domain binding
MFIBAGO:0042813Wnt-activated receptor activity
MFIDAGO:0042813Wnt-activated receptor activity
MFNASGO:0042813Wnt-activated receptor activity
MFTASGO:0042813Wnt-activated receptor activity
BPIEAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0003149membranous septum morphogenesis
BPIEAGO:0003150muscular septum morphogenesis
BPIEAGO:0003151outflow tract morphogenesis
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007267cell-cell signaling
BPISSGO:0010976positive regulation of neuron projection development
BPISSGO:0030182neuron differentiation
BPIEAGO:0030514negative regulation of BMP signaling pathway
BPIEAGO:0030855epithelial cell differentiation
BPIDAGO:0035425autocrine signaling
BPIBAGO:0035567non-canonical Wnt signaling pathway
BPIMPGO:0042493response to drug
BPIMPGO:0044338canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
BPIMPGO:0044339canonical Wnt signaling pathway involved in osteoblast differentiation
BPIEAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0060022hard palate development
BPIBAGO:0060070canonical Wnt signaling pathway
BPIDAGO:0060070canonical Wnt signaling pathway
BPIGIGO:0060070canonical Wnt signaling pathway
BPNASGO:0060070canonical Wnt signaling pathway
BPTASGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPIEAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIEAGO:0090179planar cell polarity pathway involved in neural tube closure
BPTASGO:0099054presynapse assembly
BPIEAGO:1903204negative regulation of oxidative stress-induced neuron death
BPTASGO:1904886beta-catenin destruction complex disassembly
BPNASGO:1904953Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCIBAGO:0016021integral component of membrane
CCICGO:1990909Wnt signalosome

Gene expression in normal tissue: FZD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FZD1

DatabasePathway IDPathway Des.
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP3664Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP428Wnt Signaling Pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidwnt_signaling_pathwayWnt signaling network
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartawntlrp6pathwaywnt lrp6 signalling
biocartawntpathwaywnt signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4608870Asymmetric localization of PCP proteins
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD446LY 21832403
iGMDRD85Ursolic acid1
iGMDRD512nutlin 33
iGMDRD420Leucascandrolide A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FZD1