ACSL6
Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| acyl-CoA synthetase long chain family member 6 | MIM:604443 | Ensembl:ENSG00000164398 | HGNC:HGNC:16496 | PA27970 | 5q31.1 |
GO terms in ACSL6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| MF | TAS | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0102391 | decanoate-CoA ligase activity |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005778 | peroxisomal membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0001676 | long-chain fatty acid metabolic process |
| BP | NAS | GO:0006637 | acyl-CoA metabolic process |
| BP | TAS | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
Gene expression in normal tissue: ACSL6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACSL6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| kegg | hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04146 | Peroxisome - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| humancyc | FAO-PWY | fatty acid β-oxidation |
| humancyc | PWY-5143 | fatty acid activation |
| humancyc | PWY-6000 | γ-linolenate biosynthesis |
| humancyc | PWY-7049 | icosapentaenoate biosynthesis II (metazoa) |
| humancyc | PWY66-391 | fatty acid β-oxidation (peroxisome) |
| wikipathways | WP143 | Fatty Acid Beta Oxidation |
| wikipathways | WP357 | Fatty Acid Biosynthesis |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD780 | PP-30 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACSL6
CLASSFICATION
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