ACSL6

Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameacyl-CoA synthetase long chain family member 6
OMIM IDMIM:604443
Ensembl IDEnsembl:ENSG00000164398
HGNC IDHGNC:HGNC:16496
PHARMGKB IDPA27970
Map Location5q31.1

GO terms in ACSL6


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0004467 long-chain fatty acid-CoA ligase activity
MF TAS GO:0004467 long-chain fatty acid-CoA ligase activity
MF IEA GO:0005524 ATP binding
MF IDA GO:0042803 protein homodimerization activity
MF IEA GO:0102391 decanoate-CoA ligase activity
CC IEA GO:0005741 mitochondrial outer membrane
Showing 1 to 6 of 13 rows rows per page

Gene expression in normal tissue: ACSL6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined18Biosynthesis of secondary metabolites2DNA replication2Protein stability and degradation1Cell cycle1Longevity regulating pathway1IGFR signaling1

Pathways in ACSL6


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-556833 Metabolism of lipids
reactome R-HSA-75105 Fatty acyl-CoA biosynthesis
reactome R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs
reactome R-HSA-8978868 Fatty acid metabolism
kegg hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
Showing 1 to 6 of 21 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD546 BMS-754807 2
iGMDRD779 PRL-3 Inhibitor I 1
iGMDRD494 Neopeltolide 4
iGMDRD781 Sirolimus 3
Showing 1 to 4 of 26 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACSL6

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.