PIP5K1C


Summary: This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4-phosphate 5-kinase type 1 gammaMIM:606102Ensembl:ENSG00000186111HGNC:HGNC:8996PA3332919p13.3

Gene Categories:

KINASEDRUGGABLE GENOME

GO terms in PIP5K1C


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPTASGO:0006909phagocytosis
BPTASGO:0014066regulation of phosphatidylinositol 3-kinase signaling
BPTASGO:0016079synaptic vesicle exocytosis
BPTASGO:0030036actin cytoskeleton organization
BPTASGO:0030593neutrophil chemotaxis
BPTASGO:0034333adherens junction assembly
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048488synaptic vesicle endocytosis
BPTASGO:0061024membrane organization
BPTASGO:0072583clathrin-dependent endocytosis
BPTASGO:0098609cell-cell adhesion
CCIEAGO:0001891phagocytic cup
CCTASGO:0001931uropod
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005925focal adhesion
CCIDAGO:0010008endosome membrane
CCIEAGO:0032587ruffle membrane
CCIEAGO:0098793presynapse
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity
MFTASGO:00528111-phosphatidylinositol-3-phosphate 4-kinase activity
MFTASGO:0052812phosphatidylinositol-3,4-bisphosphate 5-kinase activity

Gene expression in normal tissue: PIP5K1C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIP5K1C


DatabasePathway IDPathway Des.
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP51Regulation of Actin Cytoskeleton
netpathPathway_BCRBCR
pidarf6_traffickingpathwayArf6 trafficking events
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidncadherinpathwayN-cadherin signaling events
pidnectin_pathwayNectin adhesion pathway
pidrac1_pathwayRAC1 signaling pathway
pidrhoa_pathwayRhoA signaling pathway
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
humancycPWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD351GW843682X6
iGMDRD57Chloropentafluorobenzene3
iGMDRD154NSC237662
iGMDRD405PIK-754
iGMDRD560MK-22062
iGMDRD329Merck605
iGMDRD367Ro 28-16752
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD872BRD71372
iGMDRD505Pevonedistat1
iGMDRD103SN-385
iGMDRD121GMX17782
iGMDRD271Brefeldin A3
iGMDRD267Oligomycin A2
iGMDRD705Nakiterpiosin2
iGMDRD193Fqi12
iGMDRD446LY 21832402
iGMDRD466Chaetocin2
iGMDRD420Leucascandrolide A5
iGMDRD210AC556491
iGMDRD151CHM-12
iGMDRD554CHEMBL14341372
iGMDRD494Neopeltolide1
iGMDRD781Sirolimus4
iGMDRD577BIX012941
iGMDRD188Piperlongumine2
iGMDRD451Serdemetan3
iGMDRD64Parbendazole1
iGMDRD255SB2250021
iGMDRD318PAC-11
iGMDRD782DC-45-A23

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIP5K1C

​​​​