RASGRF1
Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Ras protein specific guanine nucleotide releasing factor 1 | MIM:606600 | Ensembl:ENSG00000058335 | HGNC:HGNC:9875 | PA34238 | 15q25.1 |
GO terms in RASGRF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0035254 | glutamate receptor binding |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | NAS | GO:0007616 | long-term memory |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | IMP | GO:0034976 | response to endoplasmic reticulum stress |
| BP | ISS | GO:0035020 | regulation of Rac protein signal transduction |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | ISS | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0046578 | regulation of Ras protein signal transduction |
| BP | ISS | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | TAS | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0048168 | regulation of neuronal synaptic plasticity |
| BP | ISS | GO:0090630 | activation of GTPase activity |
| BP | IEA | GO:2000310 | regulation of NMDA receptor activity |
| CC | ISS | GO:0005829 | cytosol |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0030426 | growth cone |
| CC | NAS | GO:0043005 | neuron projection |
Gene expression in normal tissue: RASGRF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASGRF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| wikipathways | WP1559 | TFs Regulate miRNAs related to cardiac hypertrophy |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASGRF1
CLASSFICATION
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