RASGRF1


Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Ras protein specific guanine nucleotide releasing factor 1MIM:606600Ensembl:ENSG00000058335HGNC:HGNC:9875PA3423815q25.1

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in RASGRF1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFIMPGO:0005088Ras guanyl-nucleotide exchange factor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005089Rho guanyl-nucleotide exchange factor activity
MFIEAGO:0035254glutamate receptor binding
BPTASGO:0000165MAPK cascade
BPTASGO:0007165signal transduction
BPIEAGO:0007264small GTPase mediated signal transduction
BPNASGO:0007616long-term memory
BPIEAGO:0008283cell proliferation
BPISSGO:0031175neuron projection development
BPIMPGO:0034976response to endoplasmic reticulum stress
BPISSGO:0035020regulation of Rac protein signal transduction
BPIEAGO:0035023regulation of Rho protein signal transduction
BPISSGO:0043547positive regulation of GTPase activity
BPISSGO:0046578regulation of Ras protein signal transduction
BPISSGO:0046579positive regulation of Ras protein signal transduction
BPTASGO:0046579positive regulation of Ras protein signal transduction
BPISSGO:0048167regulation of synaptic plasticity
BPIEAGO:0048168regulation of neuronal synaptic plasticity
BPISSGO:0090630activation of GTPase activity
BPIEAGO:2000310regulation of NMDA receptor activity
CCISSGO:0005829cytosol
CCNASGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0030426growth cone
CCNASGO:0043005neuron projection

Gene expression in normal tissue: RASGRF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RASGRF1


DatabasePathway IDPathway Des.
biocartacdc25pathwaycdc25 and chk1 regulatory pathway in response to dna damage
biocartag2pathwaycell cycle: g2/m checkpoint
biocartaplk3pathwayregulation of cell cycle progression by plk3
biocartaptc1pathwaysonic hedgehog receptor ptc1 regulates cell cycle
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3878ATM Signaling Network in Development and Disease
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
pidcdc42_pathwayCDC42 signaling events
pidrac1_reg_pathwayRegulation of RAC1 activity
pidras_pathwayRegulation of Ras family activation
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250023
iGMDRD870BRD636101
iGMDRD52Rotenone1
iGMDRD441TW 372
iGMDRD188Piperlongumine2
iGMDRD888Compound 442
iGMDRD577BIX012944
iGMDRD369TGX-1153
iGMDRD64Parbendazole3
iGMDRD524ISX-93
iGMDRD23Gossypol6
iGMDRD420Leucascandrolide A6
iGMDRD1008SR-II-138A3
iGMDRD599Salermide2
iGMDRD427ABT7373
iGMDRD494Neopeltolide5
iGMDRD446LY 21832403
iGMDRD193Fqi13
iGMDRD718Pyrvinium pamoate3
iGMDRD466Chaetocin4
iGMDRD271Brefeldin A3
iGMDRD137Indisulam6
iGMDRD103SN-383
iGMDRD6AM-5805
iGMDRD67PENFLURIDOL3
iGMDRD871BRD63683
iGMDRD286Nsc 6328393
iGMDRD246NPC263
iGMDRD322FK 8661
iGMDRD330BRD41322
iGMDRD248BRD43543
iGMDRD116CD4376
iGMDRD150RITA3
iGMDRD560MK-22064
iGMDRD351GW843682X3
iGMDRD123Isoevodiamine6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RASGRF1

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