RASGRF1
Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606600 Ensembl IDEnsembl:ENSG00000058335 HGNC IDHGNC:HGNC:9875 PHARMGKB IDPA34238 Map Location15q25.1 | |||||
GO terms in RASGRF1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0035254 | glutamate receptor binding |
| BP | TAS | GO:0000165 | MAPK cascade |
Gene expression in normal tissue: RASGRF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASGRF1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASGRF1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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