AFF4
Summary: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604417 Ensembl IDEnsembl:ENSG00000072364 HGNC IDHGNC:HGNC:17869 PHARMGKB IDPA142672641 Map Location5q31.1 | |||||
GO terms in AFF4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0008023 | transcription elongation factor complex |
| CC | IDA | GO:0008023 | transcription elongation factor complex |
Gene expression in normal tissue: AFF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AFF4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AFF4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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