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AFF4

Summary: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
AF4/FMR2 family member 4	MIM:604417	Ensembl:ENSG00000072364	HGNC:HGNC:17869	PA142672641	5q31.1

GO terms in AFF4

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0001650	fibrillar center
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0008023	transcription elongation factor complex
CC	IDA	GO:0008023	transcription elongation factor complex
CC	IBA	GO:0032783	ELL-EAF complex
CC	ISS	GO:0035327	transcriptionally active chromatin
BP	IEA	GO:0006355	regulation of transcription, DNA-templated
BP	TAS	GO:0006366	transcription by RNA polymerase II
BP	TAS	GO:0006368	transcription elongation from RNA polymerase II promoter
BP	IEA	GO:0007286	spermatid development
MF	IBA	GO:0003690	double-stranded DNA binding
MF	IBA	GO:0003700	DNA-binding transcription factor activity
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: AFF4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AFF4

Database	Pathway ID	Pathway Des.
reactome	R-HSA-112382	Formation of RNA Pol II elongation complex
reactome	R-HSA-674695	RNA Polymerase II Pre-transcription Events
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-75955	RNA Polymerase II Transcription Elongation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD782	DC-45-A2	2
iGMDRD318	PAC-1	1
iGMDRD138	PX 12	5
iGMDRD255	SB225002	2
iGMDRD260	FQI-2	3
iGMDRD64	Parbendazole	3
iGMDRD188	Piperlongumine	3
iGMDRD100	Zebularine	2
iGMDRD887	Compound 23 citrate	2
iGMDRD562	Navitoclax	1
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD670	ML 210	1
iGMDRD494	Neopeltolide	2
iGMDRD126	Tipifarnib	3
iGMDRD433	Lexibulin	4
iGMDRD151	CHM-1	3
iGMDRD420	Leucascandrolide A	3
iGMDRD466	Chaetocin	1
iGMDRD446	LY 2183240	2
iGMDRD639	YK 4-279	2
iGMDRD193	Fqi1	3
iGMDRD61	Kinetin riboside	2
iGMDRD705	Nakiterpiosin	4
iGMDRD105	Triptolide	2
iGMDRD231	Importazole	2
iGMDRD103	SN-38	3
iGMDRD158	NSC141540	2
iGMDRD300	Tozasertib	3
iGMDRD246	NPC26	3
iGMDRD286	Nsc 632839	2
iGMDRD662	JQ-1	2
iGMDRD329	Merck60	5
iGMDRD79	Gemcitabine	4
iGMDRD512	nutlin 3	3
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD237	ABT-751	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AFF4

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.