TEK
Summary: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TEK receptor tyrosine kinase | MIM:600221 | Ensembl:ENSG00000120156 | HGNC:HGNC:11724 | PA36441 | 9p21.2 |
GO terms in TEK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IEA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019838 | growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | ISS | GO:0001935 | endothelial cell proliferation |
| BP | TAS | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IEA | GO:0001958 | endochondral ossification |
| BP | IMP | GO:0002040 | sprouting angiogenesis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007507 | heart development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IMP | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0032878 | regulation of establishment or maintenance of cell polarity |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IMP | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043114 | regulation of vascular permeability |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IMP | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048014 | Tie signaling pathway |
| BP | TAS | GO:0050728 | negative regulation of inflammatory response |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IMP | GO:0051894 | positive regulation of focal adhesion assembly |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0060216 | definitive hemopoiesis |
| BP | ISS | GO:0060347 | heart trabecula formation |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0072012 | glomerulus vasculature development |
| BP | IMP | GO:1902533 | positive regulation of intracellular signal transduction |
| BP | IMP | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| BP | TAS | GO:2000351 | regulation of endothelial cell apoptotic process |
| BP | ISS | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IDA | GO:0001725 | stress fiber |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005902 | microvillus |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009925 | basal plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0045121 | membrane raft |
Gene expression in normal tissue: TEK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TEK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | shp2_pathway | SHP2 signaling |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD150 | RITA | 10 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 7 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD209 | BRD6340 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD356 | PNU-74654 | 4 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD435 | BI-2536 | 5 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD434 | BMS-536924 | 9 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD505 | Pevonedistat | 8 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD444 | Tivantinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TEK
CLASSFICATION
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