TEK


Summary: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in TEK


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004672 protein kinase activity
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF IDA GO:0004713 protein tyrosine kinase activity
MF TAS GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
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Gene expression in normal tissue: TEK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TEK


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-109582 Hemostasis
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-202733 Cell surface interactions at the vascular wall
reactome R-HSA-202733 Cell surface interactions at the vascular wall
reactome R-HSA-210993 Tie2 Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD79 Gemcitabine 2
iGMDRD150 RITA 10
iGMDRD237 ABT-751 5
iGMDRD698 Neratinib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TEK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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