NOVA1
Summary: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NOVA alternative splicing regulator 1 | MIM:602157 | Ensembl:ENSG00000139910 | HGNC:HGNC:7886 | PA31688 | 14q12 |
GO terms in NOVA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IEA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0006396 | RNA processing |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007626 | locomotory behavior |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | IEA | GO:0051252 | regulation of RNA metabolic process |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0003729 | mRNA binding |
Gene expression in normal tissue: NOVA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOVA1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD901 | ELCPK | 6 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD511 | CHEMBL399379 | 1 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD351 | GW843682X | 9 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOVA1
CLASSFICATION
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