PPM1E
Summary: This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase, Mg2+/Mn2+ dependent 1E | Ensembl:ENSG00000175175 | HGNC:HGNC:19322 | PA134943567 | 17q22 |
GO terms in PPM1E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0035690 | cellular response to drug |
| BP | IDA | GO:0035970 | peptidyl-threonine dephosphorylation |
| BP | IDA | GO:0051496 | positive regulation of stress fiber assembly |
Gene expression in normal tissue: PPM1E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPM1E
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD210 | AC55649 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPM1E
CLASSFICATION
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