PDPK1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 3-phosphoinositide dependent protein kinase 1 | MIM:605213 | Ensembl:ENSG00000140992 | HGNC:HGNC:8816 | PA33160 | 16p13.3 |
GO terms in PDPK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0016020 | membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0042995 | cell projection |
| CC | IEA | GO:0043204 | perikaryon |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0003323 | type B pancreatic cell development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0006972 | hyperosmotic response |
| BP | IMP | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0010518 | positive regulation of phospholipase activity |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IMP | GO:0016477 | cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0019722 | calcium-mediated signaling |
| BP | TAS | GO:0030036 | actin cytoskeleton organization |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IDA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IDA | GO:0032148 | activation of protein kinase B activity |
| BP | TAS | GO:0032148 | activation of protein kinase B activity |
| BP | IMP | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IMP | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043304 | regulation of mast cell degranulation |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048041 | focal adhesion assembly |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IDA | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IMP | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IMP | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IMP | GO:1903672 | positive regulation of sprouting angiogenesis |
| BP | IMP | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| BP | IEA | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity |
| MF | IEA | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IMP | GO:0016004 | phospholipase activator activity |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0043274 | phospholipase binding |
Gene expression in normal tissue: PDPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDPK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165158 | Activation of AKT2 |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-392451 | G beta:gamma signalling through PI3Kgamma |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-444257 | RSK activation |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | plcpathway | phospholipase c signaling pathway |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | raspathway | ras signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fgf_pathway | FGF signaling pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00391 | Insulin Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD234 | Lomeguatrib | 1 |
| iGMDRD563 | AT-406 | 1 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD210 | AC55649 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD577 | BIX01294 | 16 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD255 | SB225002 | 7 |
| iGMDRD983 | PI3K pathway inhibitor | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD294 | Batimastat | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDPK1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.