GO terms in PDPK1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005925focal adhesion
CCIEAGO:0014069postsynaptic density
CCIEAGO:0016020membrane
CCIEAGO:0031410cytoplasmic vesicle
CCIDAGO:0042995cell projection
CCIEAGO:0043204perikaryon
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0003323type B pancreatic cell development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0006469negative regulation of protein kinase activity
BPIEAGO:0006972hyperosmotic response
BPIMPGO:0007173epidermal growth factor receptor signaling pathway
BPIMPGO:0010518positive regulation of phospholipase activity
BPIEAGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIMPGO:0016477cell migration
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIMPGO:0019722calcium-mediated signaling
BPTASGO:0030036actin cytoskeleton organization
BPTASGO:0030168platelet activation
BPIDAGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPTASGO:0031295T cell costimulation
BPIDAGO:0032148activation of protein kinase B activity
BPTASGO:0032148activation of protein kinase B activity
BPIMPGO:0032869cellular response to insulin stimulus
BPIEAGO:0034122negative regulation of toll-like receptor signaling pathway
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIMPGO:0043122regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043304regulation of mast cell degranulation
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0045766positive regulation of angiogenesis
BPTASGO:0046777protein autophosphorylation
BPIEAGO:0048041focal adhesion assembly
BPTASGO:0050852T cell receptor signaling pathway
BPIDAGO:0051281positive regulation of release of sequestered calcium ion into cytosol
BPIMPGO:0071364cellular response to epidermal growth factor stimulus
BPIMPGO:0097191extrinsic apoptotic signaling pathway
BPIMPGO:1903078positive regulation of protein localization to plasma membrane
BPIMPGO:1903672positive regulation of sprouting angiogenesis
BPIMPGO:1905564positive regulation of vascular endothelial cell proliferation
BPIEAGO:1990416cellular response to brain-derived neurotrophic factor stimulus
BPIMPGO:2000352negative regulation of endothelial cell apoptotic process
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIDAGO:00046763-phosphoinositide-dependent protein kinase activity
MFIEAGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIMPGO:0016004phospholipase activator activity
MFTASGO:0016301kinase activity
MFIEAGO:0019901protein kinase binding
MFIPIGO:0043274phospholipase binding

Gene expression in normal tissue: PDPK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDPK1


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-165158Activation of AKT2
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-392451G beta:gamma signalling through PI3Kgamma
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-444257RSK activation
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartabadpathwayregulation of bad phosphorylation
biocartabcellsurvivalpathwayb cell survival pathway
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartagcrpathwaycorticosteroids and cardioprotection
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamtorpathwaymtor signaling pathway
biocartanfatpathwaynfat and hypertrophy of the heart
biocartano1pathwayactions of nitric oxide in the heart
biocartaplcpathwayphospholipase c signaling pathway
biocartaptdinspathwayphosphoinositides and their downstream targets
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaraspathwayras signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidfaspathwayFAS (CD95) signaling pathway
pidfgf_pathwayFGF signaling pathway
pidigf1_pathwayIGF1 pathway
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtgfbrpathwayTGF-beta receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_GhrelinGhrelin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00391Insulin Signalling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD84Lovastatin acid1
iGMDRD560MK-22062
iGMDRD424Tamatinib2
iGMDRD79Gemcitabine2
iGMDRD367Ro 28-16753
iGMDRD872BRD71373
iGMDRD366PI-1034
iGMDRD234Lomeguatrib1
iGMDRD563AT-4061
iGMDRD300Tozasertib5
iGMDRD246NPC262
iGMDRD82Quiflapon1
iGMDRD42Vorinostat1
iGMDRD322FK 8661
iGMDRD158NSC1415403
iGMDRD6AM-5805
iGMDRD105Triptolide5
iGMDRD434BMS-5369246
iGMDRD77Itraconazole1
iGMDRD231Importazole1
iGMDRD267Oligomycin A1
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD61Kinetin riboside1
iGMDRD394BX-7954
iGMDRD679Bistramide A5
iGMDRD280CYTOCHALASIN B3
iGMDRD375GW-4058331
iGMDRD634SCHEMBL26080414
iGMDRD210AC556492
iGMDRD579PF7502
iGMDRD420Leucascandrolide A2
iGMDRD427ABT7373
iGMDRD546BMS-7548071
iGMDRD494Neopeltolide1
iGMDRD781Sirolimus3
iGMDRD188Piperlongumine6
iGMDRD577BIX0129416
iGMDRD888Compound 441
iGMDRD562Navitoclax6
iGMDRD780PP-304
iGMDRD369TGX-1152
iGMDRD524ISX-92
iGMDRD255SB2250027
iGMDRD983PI3K pathway inhibitor2
iGMDRD441TW 371
iGMDRD52Rotenone1
iGMDRD294Batimastat2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDPK1

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