CCNA1


Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin A1MIM:604036Ensembl:ENSG00000133101HGNC:HGNC:1577PA2614713q13.3

Gene Categories:

DRUGGABLE GENOME

GO terms in CCNA1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIBAGO:0000278mitotic cell cycle
BPIBAGO:0007088regulation of mitotic nuclear division
BPTASGO:0007141male meiosis I
BPTASGO:0007283spermatogenesis
BPIBAGO:0008284positive regulation of cell proliferation
BPTASGO:0016579protein deubiquitination
BPIBAGO:0045787positive regulation of cell cycle
BPIEAGO:0051301cell division
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIBAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0015630microtubule cytoskeleton
CCIEAGO:0097123cyclin A1-CDK2 complex
MFIBAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIBAGO:0019901protein kinase binding

Gene expression in normal tissue: CCNA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNA1


DatabasePathway IDPathway Des.
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
pidcmyb_pathwayC-MYB transcription factor network
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP179Cell Cycle
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2361Gastric Cancer Network 1
wikipathwaysWP45G1 to S cell cycle control
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin A
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559586DNA Damage/Telomere Stress Induced Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-68911G2 Phase
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartag1pathwaycell cycle: g1/s check point
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartaskp2e2fpathwaye2f1 destruction pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD546BMS-7548073
iGMDRD427ABT7372
iGMDRD781Sirolimus6
iGMDRD486Tosedostat1
iGMDRD48Dexamethasone3
iGMDRD772BRD47701
iGMDRD420Leucascandrolide A4
iGMDRD512nutlin 34
iGMDRD889Compound 7d-cis2
iGMDRD280CYTOCHALASIN B2
iGMDRD394BX-7951
iGMDRD435BI-25364
iGMDRD945ML2141
iGMDRD154NSC237662
iGMDRD219Bax channel blocker2
iGMDRD61Kinetin riboside1
iGMDRD152179324-69-74
iGMDRD267Oligomycin A3
iGMDRD77Itraconazole2
iGMDRD885Compound 1102
iGMDRD318PAC-14
iGMDRD886Compound 1541A6
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib4
iGMDRD82Quiflapon2
iGMDRD887Compound 23 citrate4
iGMDRD871BRD63682
iGMDRD562Navitoclax2
iGMDRD398Sepantronium2
iGMDRD577BIX012947
iGMDRD506Fedratinib6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNA1

​​​​