TAF1


Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TATA-box binding protein associated factor 1MIM:313650Ensembl:ENSG00000147133HGNC:HGNC:11535PA36310Xq13.1

GO terms in TAF1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIPIGO:0005667transcription factor complex
CCIBAGO:0005669transcription factor TFIID complex
CCIDAGO:0005669transcription factor TFIID complex
CCTASGO:0005669transcription factor TFIID complex
CCIDAGO:0005730nucleolus
CCIDAGO:0071339MLL1 complex
BPIDAGO:0000209protein polyubiquitination
BPISSGO:0006352DNA-templated transcription, initiation
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPICGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007049cell cycle
BPIMPGO:0010629negative regulation of gene expression
BPIMPGO:0010768negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
BPIEAGO:0016032viral process
BPIEAGO:0016573histone acetylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIGIGO:0030901midbrain development
BPIDAGO:0032092positive regulation of protein binding
BPIDAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0034644cellular response to UV
BPIDAGO:0036369transcription factor catabolic process
BPICGO:0043433negative regulation of DNA-binding transcription factor activity
BPIGIGO:0045943positive regulation of transcription by RNA polymerase I
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0046777protein autophosphorylation
BPIDAGO:0050821protein stabilization
BPISSGO:0051123RNA polymerase II transcriptional preinitiation complex assembly
BPNASGO:0060260regulation of transcription initiation from RNA polymerase II promoter
BPISSGO:0060261positive regulation of transcription initiation from RNA polymerase II promoter
BPIDAGO:0071318cellular response to ATP
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPTASGO:1902806regulation of cell cycle G1/S phase transition
BPIDAGO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
BPIDAGO:1905524negative regulation of protein autoubiquitination
BPIMPGO:2000059negative regulation of ubiquitin-dependent protein catabolic process
BPIDAGO:2000825positive regulation of androgen receptor activity
MFIGIGO:0000979RNA polymerase II core promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001075transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
MFIBAGO:0001129RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
MFIPIGO:0002039p53 binding
MFIDAGO:0003713transcription coactivator activity
MFIBAGO:0004402histone acetyltransferase activity
MFIDAGO:0004402histone acetyltransferase activity
MFNASGO:0004402histone acetyltransferase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0016301kinase activity
MFIBAGO:0017025TBP-class protein binding
MFIPIGO:0017025TBP-class protein binding
MFIBAGO:0043565sequence-specific DNA binding
MFISSGO:0043565sequence-specific DNA binding
MFISSGO:0044212transcription regulatory region DNA binding
MFIPIGO:0046982protein heterodimerization activity
MFIPIGO:0061628H3K27me3 modified histone binding
MFIPIGO:0061629RNA polymerase II sequence-specific DNA-binding transcription factor binding
MFIDAGO:0061631ubiquitin conjugating enzyme activity
MFIDAGO:0070577lysine-acetylated histone binding
MFIDAGO:1905502acetyl-CoA binding

Gene expression in normal tissue: TAF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAF1


DatabasePathway IDPathway Des.
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1643685Disease
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
kegghsa03022Basal transcription factors - Homo sapiens (human)
pidrb_1pathwayRegulation of retinoblastoma protein

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD870BRD636101
iGMDRD255SB2250023
iGMDRD138PX 122
iGMDRD268Cerulenin2
iGMDRD23Gossypol3
iGMDRD506Fedratinib3
iGMDRD562Navitoclax2
iGMDRD399Selumetinib3
iGMDRD483SCH-5290749
iGMDRD781Sirolimus3
iGMDRD144NSC953972
iGMDRD670ML 2103
iGMDRD599Salermide5
iGMDRD297Austocystin D2
iGMDRD61Kinetin riboside2
iGMDRD267Oligomycin A3
iGMDRD77Itraconazole3
iGMDRD213SMR0000686502
iGMDRD105Triptolide1
iGMDRD158NSC1415403
iGMDRD246NPC266
iGMDRD147Prima-12
iGMDRD871BRD63683
iGMDRD882CIL412
iGMDRD150RITA3
iGMDRD248BRD43541
iGMDRD945ML2142
iGMDRD511CHEMBL3993793
iGMDRD154NSC237662
iGMDRD211(1S,3R)-RSL36
iGMDRD177Teniposide5
iGMDRD85Ursolic acid6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF1

​​​​