TAF1
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TATA-box binding protein associated factor 1 | MIM:313650 | Ensembl:ENSG00000147133 | HGNC:HGNC:11535 | PA36310 | Xq13.1 |
GO terms in TAF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IPI | GO:0005667 | transcription factor complex |
| CC | IBA | GO:0005669 | transcription factor TFIID complex |
| CC | IDA | GO:0005669 | transcription factor TFIID complex |
| CC | TAS | GO:0005669 | transcription factor TFIID complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0071339 | MLL1 complex |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | ISS | GO:0006352 | DNA-templated transcription, initiation |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IC | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0010768 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0016573 | histone acetylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IGI | GO:0030901 | midbrain development |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IDA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IDA | GO:0036369 | transcription factor catabolic process |
| BP | IC | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IGI | GO:0045943 | positive regulation of transcription by RNA polymerase I |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | ISS | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly |
| BP | NAS | GO:0060260 | regulation of transcription initiation from RNA polymerase II promoter |
| BP | ISS | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
| BP | IDA | GO:0071318 | cellular response to ATP |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | TAS | GO:1902806 | regulation of cell cycle G1/S phase transition |
| BP | IDA | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| BP | IDA | GO:1905524 | negative regulation of protein autoubiquitination |
| BP | IMP | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:2000825 | positive regulation of androgen receptor activity |
| MF | IGI | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly |
| MF | IBA | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | NAS | GO:0004402 | histone acetyltransferase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IBA | GO:0017025 | TBP-class protein binding |
| MF | IPI | GO:0017025 | TBP-class protein binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | ISS | GO:0043565 | sequence-specific DNA binding |
| MF | ISS | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0061628 | H3K27me3 modified histone binding |
| MF | IPI | GO:0061629 | RNA polymerase II sequence-specific DNA-binding transcription factor binding |
| MF | IDA | GO:0061631 | ubiquitin conjugating enzyme activity |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
| MF | IDA | GO:1905502 | acetyl-CoA binding |
Gene expression in normal tissue: TAF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD483 | SCH-529074 | 9 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD177 | Teniposide | 5 |
| iGMDRD85 | Ursolic acid | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAF1
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