TRIP13
Summary: This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thyroid hormone receptor interactor 13 | MIM:604507 | Ensembl:ENSG00000071539 | HGNC:HGNC:12307 | PA36986 | 5p15.33 |
Gene Categories:
DNA REPAIRGO terms in TRIP13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001556 | oocyte maturation |
| BP | ISS | GO:0006302 | double-strand break repair |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | ISS | GO:0007130 | synaptonemal complex assembly |
| BP | IBA | GO:0007131 | reciprocal meiotic recombination |
| BP | ISS | GO:0007131 | reciprocal meiotic recombination |
| BP | IEA | GO:0007141 | male meiosis I |
| BP | IEA | GO:0007144 | female meiosis I |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007286 | spermatid development |
| BP | ISS | GO:0048477 | oogenesis |
| BP | IBA | GO:0051598 | meiotic recombination checkpoint |
| BP | IEA | GO:1903506 | regulation of nucleic acid-templated transcription |
| CC | IEA | GO:0001673 | male germ cell nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005694 | chromosome |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: TRIP13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIP13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD781 | Sirolimus | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIP13
CLASSFICATION
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