NEK7
Summary: NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 7 | MIM:606848 | Ensembl:ENSG00000151414 | HGNC:HGNC:13386 | PA31551 | 1q31.3 |
GO terms in NEK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0000922 | spindle pole |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IEA | GO:0005874 | microtubule |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | TAS | GO:0051225 | spindle assembly |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
Gene expression in normal tissue: NEK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD414 | MST-312 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK7
CLASSFICATION
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