ERC1

Summary: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameELKS/RAB6-interacting/CAST family member 1
OMIM IDMIM:607127
Ensembl IDEnsembl:ENSG00000082805
HGNC IDHGNC:HGNC:17072
PHARMGKB IDPA134970875
Map Location12p13.33

GO terms in ERC1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000139 Golgi membrane
CC ISS GO:0005737 cytoplasm
CC TAS GO:0005737 cytoplasm
CC IDA GO:0008385 IkappaB kinase complex
CC TAS GO:0042734 presynaptic membrane
CC ISS GO:0045202 synapse
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Gene expression in normal tissue: ERC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined31PI3K/MTOR signaling1Mitosis1Biosynthesis of secondary metabolites1Other, kinases1Proteasome1Longevity regulating pathway1Apoptosis regulation1

Pathways in ERC1


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Database
Pathway ID
Pathway Des.
pid il1pathway IL1-mediated signaling events
pid nfkappabcanonicalpathway Canonical NF-kappaB pathway
kegg hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
wikipathways WP2512 Integrated Lung Cancer Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD61 Kinetin riboside 3
iGMDRD152 179324-69-7 3
iGMDRD446 LY 2183240 4
iGMDRD634 SCHEMBL2608041 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERC1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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