ERC1
Summary: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ELKS/RAB6-interacting/CAST family member 1 | MIM:607127 | Ensembl:ENSG00000082805 | HGNC:HGNC:17072 | PA134970875 | 12p13.33 |
GO terms in ERC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0008385 | IkappaB kinase complex |
| CC | TAS | GO:0042734 | presynaptic membrane |
| CC | ISS | GO:0045202 | synapse |
| CC | IEA | GO:0048786 | presynaptic active zone |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0007252 | I-kappaB phosphorylation |
| BP | NAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0015031 | protein transport |
| BP | ISS | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0017137 | Rab GTPase binding |
| MF | ISS | GO:0030165 | PDZ domain binding |
| MF | NAS | GO:0043522 | leucine zipper domain binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: ERC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | il1pathway | IL1-mediated signaling events |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 7 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD434 | BMS-536924 | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERC1
CLASSFICATION
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