ERC1


Summary: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ELKS/RAB6-interacting/CAST family member 1MIM:607127Ensembl:ENSG00000082805HGNC:HGNC:17072PA13497087512p13.33

GO terms in ERC1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCISSGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0008385IkappaB kinase complex
CCTASGO:0042734presynaptic membrane
CCISSGO:0045202synapse
CCIEAGO:0048786presynaptic active zone
BPNASGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0007252I-kappaB phosphorylation
BPNASGO:0007275multicellular organism development
BPIEAGO:0015031protein transport
BPISSGO:0042147retrograde transport, endosome to Golgi
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
MFIPIGO:0005515protein binding
MFISSGO:0017137Rab GTPase binding
MFISSGO:0030165PDZ domain binding
MFNASGO:0043522leucine zipper domain binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: ERC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERC1


DatabasePathway IDPathway Des.
pidil1pathwayIL1-mediated signaling events
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
wikipathwaysWP2512Integrated Lung Cancer Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside3
iGMDRD152179324-69-73
iGMDRD446LY 21832404
iGMDRD634SCHEMBL26080416
iGMDRD297Austocystin D2
iGMDRD394BX-7952
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A2
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib7
iGMDRD151CHM-14
iGMDRD781Sirolimus4
iGMDRD577BIX012943
iGMDRD506Fedratinib4
iGMDRD780PP-301
iGMDRD562Navitoclax7
iGMDRD188Piperlongumine8
iGMDRD23Gossypol3
iGMDRD60Quinoclamine1
iGMDRD260FQI-22
iGMDRD255SB2250022
iGMDRD698Neratinib1
iGMDRD237ABT-7511
iGMDRD584VER 1550082
iGMDRD116CD4372
iGMDRD150RITA3
iGMDRD424Tamatinib1
iGMDRD329Merck602
iGMDRD366PI-1032
iGMDRD871BRD63683
iGMDRD300Tozasertib2
iGMDRD213SMR0000686502
iGMDRD267Oligomycin A1
iGMDRD77Itraconazole2
iGMDRD105Triptolide3
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin4
iGMDRD434BMS-5369247

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERC1

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