DDX1
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DEAD-box helicase 1 | MIM:601257 | Ensembl:ENSG00000079785 | HGNC:HGNC:2734 | PA27199 | 2p24.3 |
GO terms in DDX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0071920 | cleavage body |
| CC | IDA | GO:0072669 | tRNA-splicing ligase complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | NAS | GO:0000245 | spliceosomal complex assembly |
| BP | IDA | GO:0006302 | double-strand break repair |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IMP | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
| BP | NAS | GO:0006446 | regulation of translational initiation |
| BP | IEP | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0009615 | response to virus |
| BP | IDA | GO:0032508 | DNA duplex unwinding |
| BP | IEA | GO:0043330 | response to exogenous dsRNA |
| BP | IDA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| BP | IMP | GO:1903608 | protein localization to cytoplasmic stress granule |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003712 | transcription coregulator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003724 | RNA helicase activity |
| MF | IEA | GO:0003725 | double-stranded RNA binding |
| MF | IDA | GO:0004518 | nuclease activity |
| MF | IEA | GO:0004527 | exonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008026 | ATP-dependent helicase activity |
| MF | IDA | GO:0008143 | poly(A) binding |
| MF | IDA | GO:0033677 | DNA/RNA helicase activity |
Gene expression in normal tissue: DDX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2942 | DDX1 as a regulatory component of the Drosha microprocessor |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD150 | RITA | 15 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD577 | BIX01294 | 12 |
| iGMDRD329 | Merck60 | 10 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDX1
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