DDX1


Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DEAD-box helicase 1MIM:601257Ensembl:ENSG00000079785HGNC:HGNC:2734PA271992p24.3

GO terms in DDX1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0010494cytoplasmic stress granule
CCHDAGO:0016020membrane
CCIDAGO:0071920cleavage body
CCIDAGO:0072669tRNA-splicing ligase complex
CCIDAGO:1990904ribonucleoprotein complex
BPNASGO:0000245spliceosomal complex assembly
BPIDAGO:0006302double-strand break repair
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIMPGO:0006388tRNA splicing, via endonucleolytic cleavage and ligation
BPNASGO:0006446regulation of translational initiation
BPIEPGO:0007275multicellular organism development
BPIEAGO:0009615response to virus
BPIDAGO:0032508DNA duplex unwinding
BPIEAGO:0043330response to exogenous dsRNA
BPIDAGO:0090305nucleic acid phosphodiester bond hydrolysis
BPIMPGO:1903608protein localization to cytoplasmic stress granule
MFIEAGO:0003677DNA binding
MFIDAGO:0003682chromatin binding
MFIDAGO:0003712transcription coregulator activity
MFHDAGO:0003723RNA binding
MFTASGO:0003724RNA helicase activity
MFIEAGO:0003725double-stranded RNA binding
MFIDAGO:0004518nuclease activity
MFIEAGO:0004527exonuclease activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008026ATP-dependent helicase activity
MFIDAGO:0008143poly(A) binding
MFIDAGO:0033677DNA/RNA helicase activity

Gene expression in normal tissue: DDX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX1


DatabasePathway IDPathway Des.
wikipathwaysWP2942DDX1 as a regulatory component of the Drosha microprocessor
wikipathwaysWP411mRNA Processing
reactomeR-HSA-6784531tRNA processing in the nucleus
reactomeR-HSA-72306tRNA processing
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD634SCHEMBL26080415
iGMDRD280CYTOCHALASIN B2
iGMDRD394BX-7951
iGMDRD150RITA15
iGMDRD144NSC953976
iGMDRD512nutlin 33
iGMDRD772BRD47702
iGMDRD300Tozasertib3
iGMDRD147Prima-11
iGMDRD577BIX0129412
iGMDRD329Merck6010
iGMDRD398Sepantronium3
iGMDRD188Piperlongumine2
iGMDRD286Nsc 6328395
iGMDRD871BRD63683
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX1

​​​​