SCD

Summary: This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namestearoyl-CoA desaturase
OMIM IDMIM:604031
Ensembl IDEnsembl:ENSG00000099194
HGNC IDHGNC:HGNC:10571
PHARMGKB IDPA34984
Map Location10q24.31

Gene Categories:

DRUGGABLE GENOME

GO terms in SCD


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006636 unsaturated fatty acid biosynthetic process
BP TAS GO:0045540 regulation of cholesterol biosynthetic process
BP TAS GO:0046949 fatty-acyl-CoA biosynthetic process
BP IEA GO:0055114 oxidation-reduction process
BP IBA GO:1903966 monounsaturated fatty acid biosynthetic process
CC IDA GO:0005730 nucleolus
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Gene expression in normal tissue: SCD

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 2

Gene-drug pathway distribution

undefined6WNT signaling1Cytoskeleton1Cell cycle1Other, kinases1

Pathways in SCD


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Database
Pathway ID
Pathway Des.
humancyc PWY-5996 oleate biosynthesis
kegg hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
kegg hsa03320 PPAR signaling pathway - Homo sapiens (human)
kegg hsa04152 AMPK signaling pathway - Homo sapiens (human)
wikipathways WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways WP2011 SREBF and miR33 in cholesterol and lipid homeostasis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD351 GW843682X 1
iGMDRD506 Fedratinib 3
iGMDRD871 BRD6368 3
iGMDRD946 ML320 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCD

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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