SCD


Summary: This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
stearoyl-CoA desaturaseMIM:604031Ensembl:ENSG00000099194HGNC:HGNC:10571PA3498410q24.31

Gene Categories:

DRUGGABLE GENOME

GO terms in SCD


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006636unsaturated fatty acid biosynthetic process
BPTASGO:0045540regulation of cholesterol biosynthetic process
BPTASGO:0046949fatty-acyl-CoA biosynthetic process
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:1903966monounsaturated fatty acid biosynthetic process
CCIDAGO:0005730nucleolus
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCHDAGO:0016020membrane
CCIDAGO:0016021integral component of membrane
MFIBAGO:0004768stearoyl-CoA 9-desaturase activity
MFIDAGO:0004768stearoyl-CoA 9-desaturase activity
MFTASGO:0004768stearoyl-CoA 9-desaturase activity
MFIBAGO:0005506iron ion binding
MFIDAGO:0005506iron ion binding
MFIDAGO:0016491oxidoreductase activity

Gene expression in normal tissue: SCD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCD


DatabasePathway IDPathway Des.
humancycPWY-5996oleate biosynthesis
kegghsa01040Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2011SREBF and miR33 in cholesterol and lipid homeostasis
wikipathwaysWP236Adipogenesis
wikipathwaysWP2706Activation of gene expression by SREBF (SREBP)
wikipathwaysWP2874Liver X Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP357Fatty Acid Biosynthesis
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4011Steatosis AOP
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-75105Fatty acyl-CoA biosynthesis
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-8978868Fatty acid metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD351GW843682X1
iGMDRD506Fedratinib3
iGMDRD871BRD63683
iGMDRD946ML3201
iGMDRD384EHT-18641
iGMDRD712BRD-K492906161
iGMDRD280CYTOCHALASIN B6
iGMDRD387CHIR-990211
iGMDRD126Tipifarnib6
iGMDRD150RITA3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCD

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