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SCD

Summary: This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
stearoyl-CoA desaturase	MIM:604031	Ensembl:ENSG00000099194	HGNC:HGNC:10571	PA34984	10q24.31

Gene Categories:

DRUGGABLE GENOME

GO terms in SCD

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0006636	unsaturated fatty acid biosynthetic process
BP	TAS	GO:0045540	regulation of cholesterol biosynthetic process
BP	TAS	GO:0046949	fatty-acyl-CoA biosynthetic process
BP	IEA	GO:0055114	oxidation-reduction process
BP	IBA	GO:1903966	monounsaturated fatty acid biosynthetic process
CC	IDA	GO:0005730	nucleolus
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IBA	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0005789	endoplasmic reticulum membrane
CC	TAS	GO:0005789	endoplasmic reticulum membrane
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0016021	integral component of membrane
MF	IBA	GO:0004768	stearoyl-CoA 9-desaturase activity
MF	IDA	GO:0004768	stearoyl-CoA 9-desaturase activity
MF	TAS	GO:0004768	stearoyl-CoA 9-desaturase activity
MF	IBA	GO:0005506	iron ion binding
MF	IDA	GO:0005506	iron ion binding
MF	IDA	GO:0016491	oxidoreductase activity

Gene expression in normal tissue: SCD

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCD

Database	Pathway ID	Pathway Des.
humancyc	PWY-5996	oleate biosynthesis
kegg	hsa01040	Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
kegg	hsa03320	PPAR signaling pathway - Homo sapiens (human)
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
wikipathways	WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways	WP2011	SREBF and miR33 in cholesterol and lipid homeostasis
wikipathways	WP236	Adipogenesis
wikipathways	WP2706	Activation of gene expression by SREBF (SREBP)
wikipathways	WP2874	Liver X Receptor Pathway
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP357	Fatty Acid Biosynthesis
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3942	PPAR signaling pathway
wikipathways	WP4010	Liver steatosis AOP
wikipathways	WP4011	Steatosis AOP
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactome	R-HSA-2426168	Activation of gene expression by SREBF (SREBP)
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-75105	Fatty acyl-CoA biosynthesis
reactome	R-HSA-8957322	Metabolism of steroids
reactome	R-HSA-8978868	Fatty acid metabolism

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD351	GW843682X	1
iGMDRD506	Fedratinib	3
iGMDRD871	BRD6368	3
iGMDRD946	ML320	1
iGMDRD384	EHT-1864	1
iGMDRD712	BRD-K49290616	1
iGMDRD280	CYTOCHALASIN B	6
iGMDRD387	CHIR-99021	1
iGMDRD126	Tipifarnib	6
iGMDRD150	RITA	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCD

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DATATYPES

CLASSFICATION

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