CASP4
Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecaspase 4 OMIM IDMIM:602664 Ensembl IDEnsembl:ENSG00000196954 HGNC IDHGNC:HGNC:1505 PHARMGKB IDPA26088 Map Location11q22.3 | |||||
GO terms in CASP4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0050700 | CARD domain binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Gene expression in normal tissue: CASP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | irespathway | internal ribosome entry pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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