CASP4
Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 4 | MIM:602664 | Ensembl:ENSG00000196954 | HGNC:HGNC:1505 | PA26088 | 11q22.3 |
GO terms in CASP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0050700 | CARD domain binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| MF | IBA | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| MF | IBA | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IBA | GO:0050727 | regulation of inflammatory response |
| BP | IMP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IMP | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | IBA | GO:0097194 | execution phase of apoptosis |
| BP | IBA | GO:0097194 | execution phase of apoptosis |
| BP | IDA | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:1904646 | cellular response to amyloid-beta |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0072557 | IPAF inflammasome complex |
| CC | IBA | GO:0072559 | NLRP3 inflammasome complex |
| CC | IBA | GO:0097169 | AIM2 inflammasome complex |
Gene expression in normal tissue: CASP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | irespathway | internal ribosome entry pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 6 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD126 | Tipifarnib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP4
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.