CASP4


Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602664
PHARMGKB IDPA26088
Map Location11q22.3

Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in CASP4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004197 cysteine-type endopeptidase activity
MF IDA GO:0004197 cysteine-type endopeptidase activity
MF IPI GO:0050700 CARD domain binding
MF IBA GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
MF IBA GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
MF IBA GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Gene expression in normal tissue: CASP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASP4


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Database
Pathway ID
Pathway Des.
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP254 Apoptosis
wikipathways WP3639 Apoptotic Signaling Pathway
kegg hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
biocarta caspasepathway caspase cascade in apoptosis
biocarta irespathway internal ribosome entry pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD945 ML214 6
iGMDRD353 PD0325901 2
iGMDRD297 Austocystin D 4
iGMDRD562 Navitoclax 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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