Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008].

bone morphogenetic protein receptor type 1AMIM:601299Ensembl:ENSG00000107779HGNC:HGNC:1076PA2538610q23.2

GO terms in BMPR1A

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004675transmembrane receptor protein serine/threonine kinase activity
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005025transforming growth factor beta receptor activity, type I
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIDAGO:0042803protein homodimerization activity
MFIBAGO:0046332SMAD binding
MFIDAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFISSGO:0098821BMP receptor activity
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCICGO:1990712HFE-transferrin receptor complex
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001707mesoderm formation
BPIEAGO:0001880Mullerian duct regression
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0002062chondrocyte differentiation
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003161cardiac conduction system development
BPISSGO:0003183mitral valve morphogenesis
BPISSGO:0003186tricuspid valve morphogenesis
BPISSGO:0003203endocardial cushion morphogenesis
BPISSGO:0003215cardiac right ventricle morphogenesis
BPISSGO:0003222ventricular trabecula myocardium morphogenesis
BPISSGO:0003223ventricular compact myocardium morphogenesis
BPISSGO:0003272endocardial cushion formation
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006955immune response
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIBAGO:0007389pattern specification process
BPIEAGO:0007398ectoderm development
BPIEAGO:0009950dorsal/ventral axis specification
BPISSGO:0010665regulation of cardiac muscle cell apoptotic process
BPIDAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIEAGO:0014032neural crest cell development
BPIMPGO:0014912negative regulation of smooth muscle cell migration
BPIEAGO:0019827stem cell population maintenance
BPIEAGO:0021983pituitary gland development
BPIEAGO:0021998neural plate mediolateral regionalization
BPIEAGO:0030324lung development
BPIMPGO:0030501positive regulation of bone mineralization
BPICGO:0030509BMP signaling pathway
BPIDAGO:0030509BMP signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIEAGO:0035137hindlimb morphogenesis
BPISSGO:0035912dorsal aorta morphogenesis
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0042733embryonic digit morphogenesis
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048352paraxial mesoderm structural organization
BPIEAGO:0048368lateral mesoderm development
BPIEAGO:0048378regulation of lateral mesodermal cell fate specification
BPIEAGO:0048382mesendoderm development
BPIEAGO:0048568embryonic organ development
BPIEAGO:0048589developmental growth
BPIEAGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0050768negative regulation of neurogenesis
BPIEAGO:0060021roof of mouth development
BPISSGO:0060043regulation of cardiac muscle cell proliferation
BPISSGO:0060045positive regulation of cardiac muscle cell proliferation
BPIDAGO:0060391positive regulation of SMAD protein signal transduction
BPIEAGO:0060914heart formation
BPICGO:0061312BMP signaling pathway involved in heart development
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPIMPGO:0071773cellular response to BMP stimulus
BPIEAGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPISSGO:1904414positive regulation of cardiac ventricle development
BPIMPGO:1904707positive regulation of vascular smooth muscle cell proliferation
BPISSGO:1905285fibrous ring of heart morphogenesis
BPISSGO:1905292regulation of neural crest cell differentiation
BPIEAGO:2000772regulation of cellular senescence

Gene expression in normal tissue: BMPR1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BMPR1A

DatabasePathway IDPathway Des.
wikipathwaysWP1425Bone Morphogenic Protein (BMP) Signalling and Regulation
wikipathwaysWP1591Heart Development
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP474Endochondral Ossification
humancycPWY66-11BMP Signalling Pathway
pidbmppathwayBMP receptor signaling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
biocartaalkpathwayalk in cardiac myocytes
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD84Lovastatin acid3
iGMDRD639YK 4-2793
iGMDRD286Nsc 6328394

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMPR1A