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BMPR1A

Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
bone morphogenetic protein receptor type 1A	MIM:601299	Ensembl:ENSG00000107779	HGNC:HGNC:1076	PA25386	10q23.2

Gene Categories:

CELL SURFACE KINASE SERINE THREONINE KINASE EXTERNAL SIDE OF PLASMA MEMBRANE CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in BMPR1A

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
MF	IBA	GO:0005024	transforming growth factor beta-activated receptor activity
MF	IBA	GO:0005025	transforming growth factor beta receptor activity, type I
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	IBA	GO:0019838	growth factor binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	IBA	GO:0046332	SMAD binding
MF	IDA	GO:0046332	SMAD binding
MF	IEA	GO:0046872	metal ion binding
MF	ISS	GO:0098821	BMP receptor activity
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IMP	GO:0005901	caveola
CC	IDA	GO:0009897	external side of plasma membrane
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0030425	dendrite
CC	IEA	GO:0043025	neuronal cell body
CC	IBA	GO:0043235	receptor complex
CC	IC	GO:1990712	HFE-transferrin receptor complex
BP	IEA	GO:0001701	in utero embryonic development
BP	IEA	GO:0001707	mesoderm formation
BP	IEA	GO:0001756	somitogenesis
BP	IEA	GO:0001880	Mullerian duct regression
BP	IEA	GO:0002053	positive regulation of mesenchymal cell proliferation
BP	IEA	GO:0002062	chondrocyte differentiation
BP	ISS	GO:0003148	outflow tract septum morphogenesis
BP	ISS	GO:0003151	outflow tract morphogenesis
BP	ISS	GO:0003161	cardiac conduction system development
BP	ISS	GO:0003183	mitral valve morphogenesis
BP	ISS	GO:0003186	tricuspid valve morphogenesis
BP	ISS	GO:0003203	endocardial cushion morphogenesis
BP	ISS	GO:0003215	cardiac right ventricle morphogenesis
BP	ISS	GO:0003222	ventricular trabecula myocardium morphogenesis
BP	ISS	GO:0003223	ventricular compact myocardium morphogenesis
BP	ISS	GO:0003272	endocardial cushion formation
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0006955	immune response
BP	IBA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	TAS	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	IBA	GO:0007389	pattern specification process
BP	IEA	GO:0007398	ectoderm development
BP	IEA	GO:0009950	dorsal/ventral axis specification
BP	ISS	GO:0010665	regulation of cardiac muscle cell apoptotic process
BP	IDA	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
BP	IEA	GO:0014032	neural crest cell development
BP	IMP	GO:0014912	negative regulation of smooth muscle cell migration
BP	IEA	GO:0019827	stem cell population maintenance
BP	IEA	GO:0021983	pituitary gland development
BP	IEA	GO:0021998	neural plate mediolateral regionalization
BP	IEA	GO:0030324	lung development
BP	IMP	GO:0030501	positive regulation of bone mineralization
BP	IC	GO:0030509	BMP signaling pathway
BP	IDA	GO:0030509	BMP signaling pathway
BP	TAS	GO:0030509	BMP signaling pathway
BP	IEA	GO:0035137	hindlimb morphogenesis
BP	ISS	GO:0035912	dorsal aorta morphogenesis
BP	IEA	GO:0042475	odontogenesis of dentin-containing tooth
BP	IEA	GO:0042733	embryonic digit morphogenesis
BP	IMP	GO:0045669	positive regulation of osteoblast differentiation
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048352	paraxial mesoderm structural organization
BP	IEA	GO:0048368	lateral mesoderm development
BP	IEA	GO:0048378	regulation of lateral mesodermal cell fate specification
BP	IEA	GO:0048382	mesendoderm development
BP	IEA	GO:0048568	embryonic organ development
BP	IEA	GO:0048589	developmental growth
BP	IEA	GO:0050679	positive regulation of epithelial cell proliferation
BP	IEA	GO:0050768	negative regulation of neurogenesis
BP	IEA	GO:0060021	roof of mouth development
BP	ISS	GO:0060043	regulation of cardiac muscle cell proliferation
BP	ISS	GO:0060045	positive regulation of cardiac muscle cell proliferation
BP	IDA	GO:0060391	positive regulation of SMAD protein signal transduction
BP	IEA	GO:0060914	heart formation
BP	IC	GO:0061312	BMP signaling pathway involved in heart development
BP	ISS	GO:0061626	pharyngeal arch artery morphogenesis
BP	IMP	GO:0071773	cellular response to BMP stimulus
BP	IEA	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
BP	ISS	GO:1904414	positive regulation of cardiac ventricle development
BP	IMP	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
BP	ISS	GO:1905285	fibrous ring of heart morphogenesis
BP	ISS	GO:1905292	regulation of neural crest cell differentiation
BP	IEA	GO:2000772	regulation of cellular senescence

Gene expression in normal tissue: BMPR1A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BMPR1A

Database	Pathway ID	Pathway Des.
wikipathways	WP1425	Bone Morphogenic Protein (BMP) Signalling and Regulation
wikipathways	WP1591	Heart Development
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP2804	Hair Follicle Development- Induction (Part 1 of 3)
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP2858	Ectoderm Differentiation
wikipathways	WP3874	Canonical and Non-Canonical TGF-B signaling
wikipathways	WP3931	ESC Pluripotency Pathways
wikipathways	WP474	Endochondral Ossification
humancyc	PWY66-11	BMP Signalling Pathway
pid	bmppathway	BMP receptor signaling
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)
biocarta	alkpathway	alk in cardiac myocytes
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-201451	Signaling by BMP
reactome	R-HSA-9006936	Signaling by TGF-beta family members

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD801	2,4-dideoxy-DC-45-A2	3
iGMDRD781	Sirolimus	3
iGMDRD870	BRD63610	1
iGMDRD150	RITA	2
iGMDRD6	AM-580	6
iGMDRD148	Pifithrin-mu	3
iGMDRD84	Lovastatin acid	3
iGMDRD158	NSC141540	2
iGMDRD505	Pevonedistat	3
iGMDRD64	Parbendazole	3
iGMDRD123	Isoevodiamine	3
iGMDRD639	YK 4-279	3
iGMDRD329	Merck60	5
iGMDRD562	Navitoclax	2
iGMDRD286	Nsc 632839	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMPR1A

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DATATYPES

CLASSFICATION

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