CDH11
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecadherin 11 OMIM IDMIM:600023 Ensembl IDEnsembl:ENSG00000140937 HGNC IDHGNC:HGNC:1750 PHARMGKB IDPA26284 Map Location16q21 | |||||
GO terms in CDH11
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | NAS | GO:0001503 | ossification |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
Gene expression in normal tissue: CDH11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDH11
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDH11
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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