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CDH11

Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cadherin 11	MIM:600023	Ensembl:ENSG00000140937	HGNC:HGNC:1750	PA26284	16q21

GO terms in CDH11

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000902	cell morphogenesis
BP	TAS	GO:0001501	skeletal system development
BP	NAS	GO:0001503	ossification
BP	IBA	GO:0007043	cell-cell junction assembly
BP	TAS	GO:0007155	cell adhesion
BP	IBA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	IEA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	IBA	GO:0007275	multicellular organism development
BP	IBA	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
BP	IEA	GO:0021957	corticospinal tract morphogenesis
BP	IBA	GO:0031175	neuron projection development
BP	IBA	GO:0034332	adherens junction organization
BP	TAS	GO:0034332	adherens junction organization
BP	IBA	GO:0044331	cell-cell adhesion mediated by cadherin
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005913	cell-cell adherens junction
CC	IBA	GO:0009986	cell surface
CC	IEA	GO:0016021	integral component of membrane
CC	IBA	GO:0016342	catenin complex
CC	HDA	GO:0070062	extracellular exosome
MF	IBA	GO:0005509	calcium ion binding
MF	IEA	GO:0005509	calcium ion binding
MF	IBA	GO:0008092	cytoskeletal protein binding
MF	IBA	GO:0042803	protein homodimerization activity
MF	IBA	GO:0045296	cadherin binding

Gene expression in normal tissue: CDH11

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDH11

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-418990	Adherens junctions interactions
reactome	R-HSA-421270	Cell-cell junction organization
reactome	R-HSA-446728	Cell junction organization

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD512	nutlin 3	3
iGMDRD79	Gemcitabine	2
iGMDRD144	NSC95397	4
iGMDRD424	Tamatinib	2
iGMDRD116	CD437	3
iGMDRD150	RITA	3
iGMDRD61	Kinetin riboside	3
iGMDRD152	179324-69-7	4
iGMDRD499	PDMP	2
iGMDRD351	GW843682X	3
iGMDRD446	LY 2183240	3
iGMDRD297	Austocystin D	2
iGMDRD255	SB225002	4
iGMDRD251	ML162	2
iGMDRD137	Indisulam	4
iGMDRD138	PX 12	1
iGMDRD121	GMX1778	2
iGMDRD103	SN-38	3
iGMDRD289	Parthenolide	2
iGMDRD577	BIX01294	1
iGMDRD399	Selumetinib	4
iGMDRD414	MST-312	6
iGMDRD286	Nsc 632839	5
iGMDRD188	Piperlongumine	9
iGMDRD322	FK 866	1
iGMDRD23	Gossypol	2
iGMDRD263	AACOCF3	1
iGMDRD369	TGX-115	3
iGMDRD505	Pevonedistat	2
iGMDRD886	Compound 1541A	2
iGMDRD300	Tozasertib	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDH11

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DATATYPES

CLASSFICATION

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