CLASP1
Summary: CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytoplasmic linker associated protein 1 | MIM:605852 | Ensembl:ENSG00000074054 | HGNC:HGNC:17088 | PA38436 | 2q14.2-q14.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CLASP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002162 | dystroglycan binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IMP | GO:0008017 | microtubule binding |
| MF | IMP | GO:0043515 | kinetochore binding |
| MF | IDA | GO:0051010 | microtubule plus-end binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IGI | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0001578 | microtubule bundle formation |
| BP | IMP | GO:0006903 | vesicle targeting |
| BP | IMP | GO:0007020 | microtubule nucleation |
| BP | IGI | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IMP | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0007052 | mitotic spindle organization |
| BP | NAS | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0010458 | exit from mitosis |
| BP | IMP | GO:0010470 | regulation of gastrulation |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IMP | GO:0010717 | regulation of epithelial to mesenchymal transition |
| BP | IMP | GO:0030953 | astral microtubule organization |
| BP | IMP | GO:0031023 | microtubule organizing center organization |
| BP | IMP | GO:0031111 | negative regulation of microtubule polymerization or depolymerization |
| BP | ISS | GO:0031116 | positive regulation of microtubule polymerization |
| BP | IMP | GO:0034453 | microtubule anchoring |
| BP | IMP | GO:0040001 | establishment of mitotic spindle localization |
| BP | IMP | GO:0045921 | positive regulation of exocytosis |
| BP | IDA | GO:0051294 | establishment of spindle orientation |
| BP | IGI | GO:0051294 | establishment of spindle orientation |
| BP | IMP | GO:0051294 | establishment of spindle orientation |
| BP | IDA | GO:0051301 | cell division |
| BP | IMP | GO:0051497 | negative regulation of stress fiber assembly |
| BP | IMP | GO:0051893 | regulation of focal adhesion assembly |
| BP | IGI | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | IMP | GO:0090091 | positive regulation of extracellular matrix disassembly |
| BP | ISS | GO:0090162 | establishment of epithelial cell polarity |
| BP | ISS | GO:0090307 | mitotic spindle assembly |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IMP | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells |
| BP | IGI | GO:1904261 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| BP | IMP | GO:1904261 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005828 | kinetochore microtubule |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005938 | cell cortex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030981 | cortical microtubule cytoskeleton |
| CC | IDA | GO:0031592 | centrosomal corona |
| CC | ISS | GO:0035371 | microtubule plus-end |
| CC | IDA | GO:0045180 | basal cortex |
Gene expression in normal tissue: CLASP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLASP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428890 | Role of ABL in ROBO-SLIT signaling |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD150 | RITA | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD512 | nutlin 3 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLASP1
CLASSFICATION
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