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CLASP1

Summary: CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecytoplasmic linker associated protein 1 OMIM IDMIM:605852 Ensembl IDEnsembl:ENSG00000074054 HGNC IDHGNC:HGNC:17088 PHARMGKB IDPA38436 Map Location2q14.2-q14.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CLASP1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0002162	dystroglycan binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008017	microtubule binding
MF	IMP	GO:0008017	microtubule binding
MF	IMP	GO:0043515	kinetochore binding
MF	IDA	GO:0051010	microtubule plus-end binding

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Gene expression in normal tissue: CLASP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLASP1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-141424	Amplification of signal from the kinetochores
reactome	R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1852241	Organelle biogenesis and maintenance

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD552	AZD-1775	3
iGMDRD505	Pevonedistat	1
iGMDRD353	PD0325901	1
iGMDRD100	Zebularine	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLASP1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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