EEF2K
Summary: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic elongation factor 2 kinase | MIM:606968 | Ensembl:ENSG00000103319 | HGNC:HGNC:24615 | PA134992891 | 16p12.2 |
GO terms in EEF2K
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0043197 | dendritic spine |
| BP | IEA | GO:0002931 | response to ischemia |
| BP | TAS | GO:0006414 | translational elongation |
| BP | IEA | GO:0031952 | regulation of protein autophosphorylation |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045807 | positive regulation of endocytosis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:0071320 | cellular response to cAMP |
| BP | IEA | GO:0071454 | cellular response to anoxia |
| BP | IEA | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| BP | IEA | GO:1990637 | response to prolactin |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004686 | elongation factor-2 kinase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008135 | translation factor activity, RNA binding |
Gene expression in normal tissue: EEF2K
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EEF2K
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD687 | I-BET151 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD653 | NVP-BSK805 | 1 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD480 | KU0060648 | 1 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EEF2K
CLASSFICATION
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