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EEF2K

Summary: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameeukaryotic elongation factor 2 kinase OMIM IDMIM:606968 Ensembl IDEnsembl:ENSG00000103319 HGNC IDHGNC:HGNC:24615 PHARMGKB IDPA134992891 Map Location16p12.2

Gene Categories:

KINASE SERINE THREONINE KINASE DRUGGABLE GENOME

GO terms in EEF2K

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0014069	postsynaptic density
CC	IEA	GO:0043197	dendritic spine
BP	IEA	GO:0002931	response to ischemia
BP	TAS	GO:0006414	translational elongation

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Gene expression in normal tissue: EEF2K

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EEF2K

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Database	Pathway ID	Pathway Des.
pid	mtor_4pathway	mTOR signaling pathway
pid	p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
kegg	hsa04921	Oxytocin signaling pathway - Homo sapiens (human)
wikipathways	WP107	Translation Factors
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD634	SCHEMBL2608041	1
iGMDRD687	I-BET151	1
iGMDRD466	Chaetocin	3
iGMDRD653	NVP-BSK805	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EEF2K

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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