CDK16
Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 16 | MIM:311550 | Ensembl:ENSG00000102225 | HGNC:HGNC:8749 | PA33095 | Xp11.3 |
GO terms in CDK16
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008021 | synaptic vesicle |
| CC | ISS | GO:0008021 | synaptic vesicle |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IEA | GO:0043005 | neuron projection |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006887 | exocytosis |
| BP | ISS | GO:0006887 | exocytosis |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0030252 | growth hormone secretion |
| BP | IBA | GO:0031175 | neuron projection development |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | IMP | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CDK16
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK16
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD679 | Bistramide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK16
CLASSFICATION
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