SUFU


Summary: The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SUFU negative regulator of hedgehog signalingMIM:607035Ensembl:ENSG00000107882HGNC:HGNC:16466PA3814610q24.32

GO terms in SUFU


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008013beta-catenin binding
MFIBAGO:0008134transcription factor binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0019901protein kinase binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIMPGO:0005737cytoplasm
CCNASGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0097542ciliary tip
CCTASGO:0097546ciliary base
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0001501skeletal system development
BPIEAGO:0001843neural tube closure
BPIEAGO:0001947heart looping
BPIEAGO:0003281ventricular septum development
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006508proteolysis
BPIBAGO:0007165signal transduction
BPTASGO:0007165signal transduction
BPTASGO:0007275multicellular organism development
BPIEAGO:0021775smoothened signaling pathway involved in ventral spinal cord interneuron specification
BPIEAGO:0021776smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
BPIEAGO:0035904aorta development
BPTASGO:0042308negative regulation of protein import into nucleus
BPIBAGO:0042994cytoplasmic sequestering of transcription factor
BPIBAGO:0043433negative regulation of DNA-binding transcription factor activity
BPTASGO:0043433negative regulation of DNA-binding transcription factor activity
BPIEAGO:0043588skin development
BPTASGO:0045668negative regulation of osteoblast differentiation
BPIMPGO:0045879negative regulation of smoothened signaling pathway
BPTASGO:0045879negative regulation of smoothened signaling pathway
BPIEAGO:0060976coronary vasculature development
BPIEAGO:1901621negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
BPIEAGO:2000059negative regulation of ubiquitin-dependent protein catabolic process

Gene expression in normal tissue: SUFU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUFU


DatabasePathway IDPathway Des.
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP47Hedgehog Signaling Pathway
netpathPathway_HedgehogHedgehog
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5632684Hedgehog 'on' state

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-383
iGMDRD5Tyrphostin AG 14783
iGMDRD171Pemetrexed1
iGMDRD289Parthenolide3
iGMDRD286Nsc 6328394
iGMDRD188Piperlongumine8
iGMDRD246NPC263
iGMDRD886Compound 1541A2
iGMDRD512nutlin 34
iGMDRD670ML 2103
iGMDRD150RITA5
iGMDRD701NVP-AUY9222
iGMDRD494Neopeltolide1
iGMDRD85Ursolic acid4
iGMDRD351GW843682X3
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin3
iGMDRD123Isoevodiamine3
iGMDRD297Austocystin D2
iGMDRD211(1S,3R)-RSL33
iGMDRD511CHEMBL3993793
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080413

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUFU

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