SUFU

Summary: The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSUFU negative regulator of hedgehog signaling
OMIM IDMIM:607035
Ensembl IDEnsembl:ENSG00000107882
HGNC IDHGNC:HGNC:16466
PHARMGKB IDPA38146
Map Location10q24.32

GO terms in SUFU


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003714 transcription corepressor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0008013 beta-catenin binding
MF IBA GO:0008134 transcription factor binding
MF IDA GO:0008134 transcription factor binding
MF IPI GO:0019901 protein kinase binding
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Gene expression in normal tissue: SUFU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined17Cell cycle1Ferroptosis1Protein stability and degradation1Chromatin histone acetylation1One carbon pool by folate1DNA replication1

Pathways in SUFU


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Database
Pathway ID
Pathway Des.
wikipathways WP4249 Hedgehog Signaling Pathway
wikipathways WP47 Hedgehog Signaling Pathway
netpath Pathway_Hedgehog Hedgehog
pid hedgehog_glipathway Hedgehog signaling events mediated by Gli proteins
kegg hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD103 SN-38 3
iGMDRD5 Tyrphostin AG 1478 3
iGMDRD171 Pemetrexed 1
iGMDRD289 Parthenolide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUFU

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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