CTTN
Summary: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecortactin OMIM IDMIM:164765 Ensembl IDEnsembl:ENSG00000085733 HGNC IDHGNC:HGNC:3338 PHARMGKB IDPA27775 Map Location11q13.3 | |||||
GO terms in CTTN
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0005522 | profilin binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | ISS | GO:0001726 | ruffle |
| CC | IEA | GO:0002102 | podosome |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: CTTN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTTN
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTTN
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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