NUP98
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nucleoporin 98 | MIM:601021 | Ensembl:ENSG00000110713 | HGNC:HGNC:8068 | PA31856 | 11p15.4 |
GO terms in NUP98
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IMP | GO:0003729 | mRNA binding |
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | IEA | GO:0008236 | serine-type peptidase activity |
| MF | IBA | GO:0017056 | structural constituent of nuclear pore |
| MF | IMP | GO:0017056 | structural constituent of nuclear pore |
| MF | NAS | GO:0017056 | structural constituent of nuclear pore |
| MF | IMP | GO:1990841 | promoter-specific chromatin binding |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005643 | nuclear pore |
| CC | NAS | GO:0005643 | nuclear pore |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0031080 | nuclear pore outer ring |
| CC | NAS | GO:0031080 | nuclear pore outer ring |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0034399 | nuclear periphery |
| CC | IDA | GO:0042405 | nuclear inclusion body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0044614 | nuclear pore cytoplasmic filaments |
| CC | IDA | GO:0044615 | nuclear pore nuclear basket |
| CC | IMP | GO:1990904 | ribonucleoprotein complex |
| BP | IBA | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
| BP | IMP | GO:0006260 | DNA replication |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006606 | protein import into nucleus |
| BP | TAS | GO:0006913 | nucleocytoplasmic transport |
| BP | NAS | GO:0006999 | nuclear pore organization |
| BP | TAS | GO:0016032 | viral process |
| BP | IBA | GO:0034398 | telomere tethering at nuclear periphery |
| BP | IMP | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| BP | IMP | GO:0051292 | nuclear pore complex assembly |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
Gene expression in normal tissue: NUP98
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUP98
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085377 | SUMOylation of SUMOylation proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD150 | RITA | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD318 | PAC-1 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUP98
CLASSFICATION
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