CDK11A

Summary: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecyclin dependent kinase 11A
OMIM IDMIM:116951
Ensembl IDEnsembl:ENSG00000008128
HGNC IDHGNC:HGNC:1730
PHARMGKB IDPA26263
Map Location1p36.33

GO terms in CDK11A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0004672 protein kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004693 cyclin-dependent protein serine/threonine kinase activity
MF IDA GO:0005524 ATP binding
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: CDK11A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1

Gene-drug pathway distribution

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Pathways in CDK11A


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
reactome R-HSA-380287 Centrosome maturation
reactome R-HSA-453274 Mitotic G2-G2/M phases
reactome R-HSA-69275 G2/M Transition
reactome R-HSA-69278 Cell Cycle, Mitotic
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD634 SCHEMBL2608041 3
iGMDRD150 RITA 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK11A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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