PTPRU
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type U | MIM:602454 | Ensembl:ENSG00000060656 | HGNC:HGNC:9683 | PA34028 | 1p35.3 |
GO terms in PTPRU
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | NAS | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0034109 | homotypic cell-cell adhesion |
| BP | IDA | GO:0034394 | protein localization to cell surface |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0098609 | cell-cell adhesion |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IMP | GO:0004725 | protein tyrosine phosphatase activity |
| MF | NAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: PTPRU
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRU
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| netpath | Pathway_KitReceptor | KitReceptor |
| wikipathways | WP581 | EPO Receptor Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD351 | GW843682X | 7 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRU
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