PTPRU


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010].

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GO terms in PTPRU


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006470 protein dephosphorylation
BP NAS GO:0007155 cell adhesion
BP NAS GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
BP IDA GO:0008285 negative regulation of cell proliferation
BP IEA GO:0030154 cell differentiation
BP IDA GO:0030336 negative regulation of cell migration
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Gene expression in normal tissue: PTPRU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRU


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1433557 Signaling by SCF-KIT
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
netpath Pathway_KitReceptor KitReceptor
wikipathways WP581 EPO Receptor Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD782 DC-45-A2 3
iGMDRD870 BRD63610 5
iGMDRD318 PAC-1 3
iGMDRD399 Selumetinib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRU

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Level
Reference ID
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Cancer
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