PRKG1
Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase cGMP-dependent 1 | MIM:176894 | Ensembl:ENSG00000185532 | HGNC:HGNC:9414 | PA33777 | 10q11.23-q21.1 |
GO terms in PRKG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001764 | neuron migration |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0016358 | dendrite development |
| BP | IEA | GO:0019934 | cGMP-mediated signaling |
| BP | TAS | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0030900 | forebrain development |
| BP | IMP | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0060087 | relaxation of vascular smooth muscle |
| BP | IMP | GO:0090331 | negative regulation of platelet aggregation |
| BP | IDA | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| BP | IDA | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004692 | cGMP-dependent protein kinase activity |
| MF | TAS | GO:0004692 | cGMP-dependent protein kinase activity |
| MF | IDA | GO:0005246 | calcium channel regulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0030553 | cGMP binding |
Gene expression in normal tissue: PRKG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-392517 | Rap1 signalling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
| reactome | R-HSA-418457 | cGMP effects |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD150 | RITA | 5 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 9 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD427 | ABT737 | 8 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD60 | Quinoclamine | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKG1
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