PRKG1


Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase cGMP-dependent 1MIM:176894Ensembl:ENSG00000185532HGNC:HGNC:9414PA3377710q11.23-q21.1

GO terms in PRKG1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001764neuron migration
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPIEAGO:0016358dendrite development
BPIEAGO:0019934cGMP-mediated signaling
BPTASGO:0030036actin cytoskeleton organization
BPIEAGO:0030900forebrain development
BPIMPGO:0043087regulation of GTPase activity
BPIEAGO:0060087relaxation of vascular smooth muscle
BPIMPGO:0090331negative regulation of platelet aggregation
BPIDAGO:1904706negative regulation of vascular smooth muscle cell proliferation
BPIDAGO:1904753negative regulation of vascular associated smooth muscle cell migration
CCIDAGO:0005737cytoplasm
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
MFIMPGO:0004672protein kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004692cGMP-dependent protein kinase activity
MFTASGO:0004692cGMP-dependent protein kinase activity
MFIDAGO:0005246calcium channel regulator activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0030553cGMP binding

Gene expression in normal tissue: PRKG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKG1


DatabasePathway IDPathway Des.
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidtxa2pathwayThromboxane A2 receptor signaling
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
biocartano1pathwayactions of nitric oxide in the heart
biocartaraccpathwayion channels and their functional role in vascular endothelium
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-392517Rap1 signalling
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects
reactomeR-HSA-418457cGMP effects

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD248BRD43541
iGMDRD330BRD41323
iGMDRD79Gemcitabine3
iGMDRD150RITA5
iGMDRD211(1S,3R)-RSL33
iGMDRD103SN-382
iGMDRD121GMX17782
iGMDRD202Curcumin4
iGMDRD137Indisulam3
iGMDRD251ML1623
iGMDRD77Itraconazole4
iGMDRD434BMS-5369246
iGMDRD329Merck603
iGMDRD286Nsc 6328393
iGMDRD871BRD63689
iGMDRD872BRD71373
iGMDRD42Vorinostat3
iGMDRD670ML 2103
iGMDRD779PRL-3 Inhibitor I3
iGMDRD427ABT7378
iGMDRD639YK 4-2793
iGMDRD193Fqi11
iGMDRD375GW-4058333
iGMDRD679Bistramide A5
iGMDRD255SB2250023
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD441TW 371
iGMDRD782DC-45-A22
iGMDRD562Navitoclax6
iGMDRD188Piperlongumine8
iGMDRD887Compound 23 citrate2
iGMDRD23Gossypol5
iGMDRD60Quinoclamine6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKG1

​​​​