NEK3
Summary: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 3 | MIM:604044 | Ensembl:ENSG00000136098 | HGNC:HGNC:7746 | PA31547 | 13q14.3 |
GO terms in NEK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | NAS | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0030424 | axon |
| BP | NAS | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0030010 | establishment of cell polarity |
| BP | IEA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0090043 | regulation of tubulin deacetylation |
Gene expression in normal tissue: NEK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Prolactin | Prolactin |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD150 | RITA | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.