NEK3

Summary: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameNIMA related kinase 3
OMIM IDMIM:604044
Ensembl IDEnsembl:ENSG00000136098
HGNC IDHGNC:HGNC:7746
PHARMGKB IDPA31547
Map Location13q14.3

GO terms in NEK3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0046872 metal ion binding
CC NAS GO:0005634 nucleus
CC IEA GO:0005737 cytoplasm
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Gene expression in normal tissue: NEK3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 33undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1

Gene-drug pathway distribution

undefined13Chromatin histone acetylation1ERK MAPK signaling1Biosynthesis of secondary metabolites1

Pathways in NEK3


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Database
Pathway ID
Pathway Des.
netpath Pathway_Prolactin Prolactin
wikipathways WP2037 Prolactin Signaling Pathway
wikipathways WP2593 JAK-STAT
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD887 Compound 23 citrate 3
iGMDRD399 Selumetinib 3
iGMDRD23 Gossypol 3
iGMDRD138 PX 12 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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