Summary: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008].

BCL2 associated agonist of cell deathMIM:603167Ensembl:ENSG00000002330HGNC:HGNC:936PA2523611q13.1

GO terms in BAD

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
BPIBAGO:0001836release of cytochrome c from mitochondria
BPIEAGO:0001836release of cytochrome c from mitochondria
BPTASGO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:0006007glucose catabolic process
BPIDAGO:0006915apoptotic process
BPTASGO:0006915apoptotic process
BPISSGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0009749response to glucose
BPTASGO:0010508positive regulation of autophagy
BPISSGO:0010918positive regulation of mitochondrial membrane potential
BPIEAGO:0019050suppression by virus of host apoptotic process
BPIEAGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0021987cerebral cortex development
BPISSGO:0032024positive regulation of insulin secretion
BPIEAGO:0032355response to estradiol
BPIEAGO:0032570response to progesterone
BPISSGO:0033133positive regulation of glucokinase activity
BPIEAGO:0033574response to testosterone
BPIEAGO:0034201response to oleic acid
BPIEAGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0042542response to hydrogen peroxide
BPISSGO:0042593glucose homeostasis
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIEAGO:0043200response to amino acid
BPIDAGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPISSGO:0044342type B pancreatic cell proliferation
BPIEAGO:0045471response to ethanol
BPIEAGO:0045579positive regulation of B cell differentiation
BPIEAGO:0045582positive regulation of T cell differentiation
BPIDAGO:0045862positive regulation of proteolysis
BPISSGO:0046031ADP metabolic process
BPISSGO:0046034ATP metabolic process
BPIBAGO:0046902regulation of mitochondrial membrane permeability
BPIMPGO:0046902regulation of mitochondrial membrane permeability
BPIDAGO:0046931pore complex assembly
BPIMPGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0051384response to glucocorticoid
BPIEAGO:0051592response to calcium ion
BPIEAGO:0060139positive regulation of apoptotic process by virus
BPIEAGO:0060154cellular process regulating host cell cycle in response to virus
BPIEAGO:0071247cellular response to chromate
BPIEPGO:0071260cellular response to mechanical stimulus
BPIDAGO:0071316cellular response to nicotine
BPIEAGO:0071396cellular response to lipid
BPIBAGO:0071456cellular response to hypoxia
BPIEPGO:0071456cellular response to hypoxia
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIBAGO:0097191extrinsic apoptotic signaling pathway
BPIMPGO:0097191extrinsic apoptotic signaling pathway
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:0097193intrinsic apoptotic signaling pathway
BPIMPGO:0097193intrinsic apoptotic signaling pathway
BPIBAGO:0097202activation of cysteine-type endopeptidase activity
BPIDAGO:0097202activation of cysteine-type endopeptidase activity
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:1901216positive regulation of neuron death
BPIEAGO:1902220positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
BPISSGO:2000078positive regulation of type B pancreatic cell development
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
MFIPIGO:0005515protein binding
MFIMPGO:0005543phospholipid binding
MFIDAGO:0008289lipid binding
MFIBAGO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process
MFIDAGO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process
MFIBAGO:0019901protein kinase binding
MFIPIGO:0019901protein kinase binding
MFIBAGO:0019903protein phosphatase binding
MFIEAGO:0030346protein phosphatase 2B binding
MFIEAGO:0043422protein kinase B binding
MFIEAGO:0046982protein heterodimerization activity
MFIEAGO:007188914-3-3 protein binding

Gene expression in normal tissue: BAD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAD

DatabasePathway IDPathway Des.
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-9006925Intracellular signaling by second messengers
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartabadpathwayregulation of bad phosphorylation
biocartaceramidepathwayceramide signaling pathway
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartaptdinspathwayphosphoinositides and their downstream targets
biocartaraspathwayras signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pidalphasynuclein_pathwayAlpha-synuclein signaling
pidceramide_pathwayCeramide signaling pathway
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidigf1_pathwayIGF1 pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4223Ras Signaling
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAD