BAD

Summary: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameBCL2 associated agonist of cell death
OMIM IDMIM:603167
Ensembl IDEnsembl:ENSG00000002330
HGNC IDHGNC:HGNC:936
PHARMGKB IDPA25236
Map Location11q13.1

GO terms in BAD


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005739 mitochondrion
CC IDA GO:0005739 mitochondrion
CC IDA GO:0005741 mitochondrial outer membrane
CC TAS GO:0005741 mitochondrial outer membrane
CC IBA GO:0005829 cytosol
CC IDA GO:0005829 cytosol
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Gene expression in normal tissue: BAD

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6

Gene-drug pathway distribution

Pathways in BAD


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-109581 Apoptosis
reactome R-HSA-109606 Intrinsic Pathway for Apoptosis
reactome R-HSA-109606 Intrinsic Pathway for Apoptosis
reactome R-HSA-111447 Activation of BAD and translocation to mitochondria
reactome R-HSA-111447 Activation of BAD and translocation to mitochondria
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD562 Navitoclax 3
iGMDRD255 SB225002 3
iGMDRD121 GMX1778 3
iGMDRD872 BRD7137 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAD

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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