BAD
Summary: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 associated agonist of cell death | MIM:603167 | Ensembl:ENSG00000002330 | HGNC:HGNC:936 | PA25236 | 11q13.1 |
GO terms in BAD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | IEA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | TAS | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IEA | GO:0006007 | glucose catabolic process |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | ISS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0009749 | response to glucose |
| BP | TAS | GO:0010508 | positive regulation of autophagy |
| BP | ISS | GO:0010918 | positive regulation of mitochondrial membrane potential |
| BP | IEA | GO:0019050 | suppression by virus of host apoptotic process |
| BP | IEA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | ISS | GO:0032024 | positive regulation of insulin secretion |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | ISS | GO:0033133 | positive regulation of glucokinase activity |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IEA | GO:0034201 | response to oleic acid |
| BP | IEA | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IDA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0044342 | type B pancreatic cell proliferation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0045579 | positive regulation of B cell differentiation |
| BP | IEA | GO:0045582 | positive regulation of T cell differentiation |
| BP | IDA | GO:0045862 | positive regulation of proteolysis |
| BP | ISS | GO:0046031 | ADP metabolic process |
| BP | ISS | GO:0046034 | ATP metabolic process |
| BP | IBA | GO:0046902 | regulation of mitochondrial membrane permeability |
| BP | IMP | GO:0046902 | regulation of mitochondrial membrane permeability |
| BP | IDA | GO:0046931 | pore complex assembly |
| BP | IMP | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051592 | response to calcium ion |
| BP | IEA | GO:0060139 | positive regulation of apoptotic process by virus |
| BP | IEA | GO:0060154 | cellular process regulating host cell cycle in response to virus |
| BP | IEA | GO:0071247 | cellular response to chromate |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IDA | GO:0071316 | cellular response to nicotine |
| BP | IEA | GO:0071396 | cellular response to lipid |
| BP | IBA | GO:0071456 | cellular response to hypoxia |
| BP | IEP | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IBA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IBA | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | IMP | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | IBA | GO:0097202 | activation of cysteine-type endopeptidase activity |
| BP | IDA | GO:0097202 | activation of cysteine-type endopeptidase activity |
| BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IEA | GO:1901216 | positive regulation of neuron death |
| BP | IEA | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| BP | ISS | GO:2000078 | positive regulation of type B pancreatic cell development |
| BP | TAS | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005543 | phospholipid binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | IBA | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| MF | IDA | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0019903 | protein phosphatase binding |
| MF | IEA | GO:0030346 | protein phosphatase 2B binding |
| MF | IEA | GO:0043422 | protein kinase B binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0071889 | 14-3-3 protein binding |
Gene expression in normal tissue: BAD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
| reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
| reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| biocarta | raspathway | ras signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | igf1_pathway | IGF1 pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_TWEAK | TWEAK |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD150 | RITA | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAD
CLASSFICATION
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