THBS3

Summary: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namethrombospondin 3
OMIM IDMIM:188062
Ensembl IDEnsembl:ENSG00000169231
HGNC IDHGNC:HGNC:11787
PHARMGKB IDPA36499
Map Location1q22

Gene Categories:

DRUGGABLE GENOME

GO terms in THBS3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IDA GO:0048471 perinuclear region of cytoplasm
BP IEA GO:0003417 growth plate cartilage development
BP NAS GO:0007160 cell-matrix adhesion
BP IEA GO:0043931 ossification involved in bone maturation
BP IEA GO:0060346 bone trabecula formation
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Gene expression in normal tissue: THBS3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 31undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 23BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8

Gene-drug pathway distribution

Pathways in THBS3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-186797 Signaling by PDGF
reactome R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
kegg hsa04145 Phagosome - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
kegg hsa04510 Focal adhesion - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD23 Gossypol 3
iGMDRD246 NPC26 3
iGMDRD562 Navitoclax 3
iGMDRD398 Sepantronium 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THBS3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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