THBS3


Summary: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thrombospondin 3MIM:188062Ensembl:ENSG00000169231HGNC:HGNC:11787PA364991q22

Gene Categories:

DRUGGABLE GENOME

GO terms in THBS3


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIDAGO:0048471perinuclear region of cytoplasm
BPIEAGO:0003417growth plate cartilage development
BPNASGO:0007160cell-matrix adhesion
BPIEAGO:0043931ossification involved in bone maturation
BPIEAGO:0060346bone trabecula formation
MFNASGO:0005509calcium ion binding
MFIDAGO:0008201heparin binding

Gene expression in normal tissue: THBS3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in THBS3


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP453Inflammatory Response Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD23Gossypol3
iGMDRD246NPC263
iGMDRD562Navitoclax3
iGMDRD398Sepantronium3
iGMDRD871BRD63682
iGMDRD887Compound 23 citrate2
iGMDRD77Itraconazole2
iGMDRD267Oligomycin A1
iGMDRD105Triptolide2
iGMDRD434BMS-5369243
iGMDRD255SB2250022
iGMDRD103SN-382
iGMDRD138PX 123
iGMDRD202Curcumin3
iGMDRD511CHEMBL3993792
iGMDRD123Isoevodiamine2
iGMDRD280CYTOCHALASIN B1
iGMDRD536PLX-47201
iGMDRD351GW843682X2
iGMDRD639YK 4-2793
iGMDRD193Fqi13
iGMDRD237ABT-7511
iGMDRD701NVP-AUY9224
iGMDRD150RITA3
iGMDRD427ABT7373
iGMDRD512nutlin 33
iGMDRD584VER 1550083
iGMDRD126Tipifarnib3
iGMDRD433Lexibulin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THBS3

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