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DEK

Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameDEK proto-oncogene OMIM IDMIM:125264 Ensembl IDEnsembl:ENSG00000124795 HGNC IDHGNC:HGNC:2768 PHARMGKB IDPA27251 Map Location6p22.3

Gene Categories:

DNA REPAIR

GO terms in DEK

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0043292	contractile fiber
BP	TAS	GO:0006357	regulation of transcription by RNA polymerase II
BP	TAS	GO:0006366	transcription by RNA polymerase II

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Gene expression in normal tissue: DEK

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DEK

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-212165	Epigenetic regulation of gene expression
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-5250913	Positive epigenetic regulation of rRNA expression
reactome	R-HSA-5250924	B-WICH complex positively regulates rRNA expression
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD123	Isoevodiamine	3
iGMDRD394	BX-795	1
iGMDRD634	SCHEMBL2608041	1
iGMDRD237	ABT-751	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DEK

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.