DEK
Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DEK proto-oncogene | MIM:125264 | Ensembl:ENSG00000124795 | HGNC:HGNC:2768 | PA27251 | 6p22.3 |
Gene Categories:
DNA REPAIRGO terms in DEK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0043292 | contractile fiber |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0019079 | viral genome replication |
| BP | TAS | GO:0045815 | positive regulation of gene expression, epigenetic |
| BP | IBA | GO:2000779 | regulation of double-strand break repair |
| BP | IMP | GO:2000779 | regulation of double-strand break repair |
| BP | IEA | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining |
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0042393 | histone binding |
| MF | IDA | GO:0042393 | histone binding |
Gene expression in normal tissue: DEK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DEK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DEK
CLASSFICATION
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