CYP1B1
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601771 Ensembl IDEnsembl:ENSG00000138061 HGNC IDHGNC:HGNC:2597 PHARMGKB IDPA27094 Map Location2p22.2 | |||||
GO terms in CYP1B1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0002930 | trabecular meshwork development |
| BP | IEA | GO:0006725 | cellular aromatic compound metabolic process |
Gene expression in normal tissue: CYP1B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP1B1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6398 | melatonin degradation I |
| humancyc | PWY-6402 | superpathway of melatonin degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| pharmgkb | PA145011118 | Estrogen Metabolism Pathway |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA165815256 | Amodiaquine Pathway, Pharmacokinetics |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP1B1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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