CYP1B1
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytochrome P450 family 1 subfamily B member 1 | MIM:601771 | Ensembl:ENSG00000138061 | HGNC:HGNC:2597 | PA27094 | 2p22.2 |
GO terms in CYP1B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0002930 | trabecular meshwork development |
| BP | IEA | GO:0006725 | cellular aromatic compound metabolic process |
| BP | IDA | GO:0006805 | xenobiotic metabolic process |
| BP | ISS | GO:0006809 | nitric oxide biosynthetic process |
| BP | ISS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007601 | visual perception |
| BP | IDA | GO:0008202 | steroid metabolic process |
| BP | IDA | GO:0008210 | estrogen metabolic process |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| BP | IEA | GO:0009404 | toxin metabolic process |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | TAS | GO:0016125 | sterol metabolic process |
| BP | IDA | GO:0019369 | arachidonic acid metabolic process |
| BP | TAS | GO:0019373 | epoxygenase P450 pathway |
| BP | ISS | GO:0030199 | collagen fibril organization |
| BP | ISS | GO:0030336 | negative regulation of cell migration |
| BP | ISS | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| BP | IDA | GO:0042572 | retinol metabolic process |
| BP | IDA | GO:0042574 | retinal metabolic process |
| BP | ISS | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0043542 | endothelial cell migration |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0046427 | positive regulation of JAK-STAT cascade |
| BP | ISS | GO:0046466 | membrane lipid catabolic process |
| BP | ISS | GO:0048514 | blood vessel morphogenesis |
| BP | TAS | GO:0055114 | oxidation-reduction process |
| BP | ISS | GO:0061304 | retinal blood vessel morphogenesis |
| BP | ISS | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IDA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0071603 | endothelial cell-cell adhesion |
| BP | TAS | GO:0097267 | omega-hydroxylase P450 pathway |
| BP | ISS | GO:2000377 | regulation of reactive oxygen species metabolic process |
| MF | IDA | GO:0004497 | monooxygenase activity |
| MF | TAS | GO:0004497 | monooxygenase activity |
| MF | IEA | GO:0005506 | iron ion binding |
| MF | IDA | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| MF | TAS | GO:0019825 | oxygen binding |
| MF | IDA | GO:0020037 | heme binding |
| MF | TAS | GO:0020037 | heme binding |
| MF | IEA | GO:0070330 | aromatase activity |
Gene expression in normal tissue: CYP1B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP1B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6398 | melatonin degradation I |
| humancyc | PWY-6402 | superpathway of melatonin degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| pharmgkb | PA145011118 | Estrogen Metabolism Pathway |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA165815256 | Amodiaquine Pathway, Pharmacokinetics |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP2001 | miR-targeted genes in adipocytes - TarBase |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2542 | Sulindac Metabolic Pathway |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2881 | Estrogen Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP43 | Oxidation by Cytochrome P450 |
| wikipathways | WP465 | Tryptophan metabolism |
| wikipathways | WP691 | Tamoxifen metabolism |
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP697 | Estrogen metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211976 | Endogenous sterols |
| reactome | R-HSA-2142670 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-2142816 | Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5579000 | Defective CYP1B1 causes Glaucoma |
| reactome | R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD255 | SB225002 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP1B1
CLASSFICATION
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