EIF5A
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 5A | MIM:600187 | Ensembl:ENSG00000132507 | HGNC:HGNC:3300 | PA27726 | 17p13.1 |
GO terms in EIF5A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | ISS | GO:0003746 | translation elongation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017070 | U6 snRNA binding |
| MF | IEA | GO:0043022 | ribosome binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| BP | IMP | GO:0006406 | mRNA export from nucleus |
| BP | IEA | GO:0006452 | translational frameshifting |
| BP | IMP | GO:0006611 | protein export from nucleus |
| BP | IDA | GO:0006913 | nucleocytoplasmic transport |
| BP | IMP | GO:0006913 | nucleocytoplasmic transport |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0045901 | positive regulation of translational elongation |
| BP | IEA | GO:0045905 | positive regulation of translational termination |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005642 | annulate lamellae |
| CC | IDA | GO:0005643 | nuclear pore |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: EIF5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF5A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP3302 | eIF5A regulation in response to inhibition of the nuclear export system |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-204626 | Hypusine synthesis from eIF5A-lysine |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD201 | SKI II | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF5A
CLASSFICATION
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