PIGU


Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol glycan anchor biosynthesis class UMIM:608528Ensembl:ENSG00000101464HGNC:HGNC:15791PA16239950620q11.22

GO terms in PIGU


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003923GPI-anchor transamidase activity
MFIMPGO:0003923GPI-anchor transamidase activity
MFIMPGO:0034235GPI anchor binding
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCICGO:0030176integral component of endoplasmic reticulum membrane
CCIBAGO:0042765GPI-anchor transamidase complex
CCIDAGO:0042765GPI-anchor transamidase complex
BPIDAGO:0006506GPI anchor biosynthetic process
BPIBAGO:0016255attachment of GPI anchor to protein
BPIMPGO:0016255attachment of GPI anchor to protein
BPTASGO:0016255attachment of GPI anchor to protein
BPIBAGO:0034394protein localization to cell surface
BPIDAGO:0046425regulation of JAK-STAT cascade

Gene expression in normal tissue: PIGU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIGU


DatabasePathway IDPathway Des.
reactomeR-HSA-162791Attachment of GPI anchor to uPAR
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
kegghsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369242
iGMDRD202Curcumin3
iGMDRD137Indisulam3
iGMDRD524ISX-93
iGMDRD505Pevonedistat3
iGMDRD147Prima-11
iGMDRD64Parbendazole6
iGMDRD888Compound 446
iGMDRD398Sepantronium2
iGMDRD780PP-301
iGMDRD286Nsc 6328392
iGMDRD871BRD63688
iGMDRD872BRD71372
iGMDRD150RITA2
iGMDRD387CHIR-990213
iGMDRD512nutlin 31
iGMDRD772BRD47702
iGMDRD307Manumycin A1
iGMDRD297Austocystin D3
iGMDRD280CYTOCHALASIN B7
iGMDRD446LY 21832403
iGMDRD341Triacsin c5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIGU

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