PIGU
Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608528 Ensembl IDEnsembl:ENSG00000101464 HGNC IDHGNC:HGNC:15791 PHARMGKB IDPA162399506 Map Location20q11.22 | |||||
GO terms in PIGU
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003923 | GPI-anchor transamidase activity |
| MF | IMP | GO:0003923 | GPI-anchor transamidase activity |
| MF | IMP | GO:0034235 | GPI anchor binding |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: PIGU
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIGU
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162791 | Attachment of GPI anchor to uPAR |
| reactome | R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIGU
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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