PIGU
Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol glycan anchor biosynthesis class U | MIM:608528 | Ensembl:ENSG00000101464 | HGNC:HGNC:15791 | PA162399506 | 20q11.22 |
GO terms in PIGU
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003923 | GPI-anchor transamidase activity |
| MF | IMP | GO:0003923 | GPI-anchor transamidase activity |
| MF | IMP | GO:0034235 | GPI anchor binding |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IC | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IBA | GO:0042765 | GPI-anchor transamidase complex |
| CC | IDA | GO:0042765 | GPI-anchor transamidase complex |
| BP | IDA | GO:0006506 | GPI anchor biosynthetic process |
| BP | IBA | GO:0016255 | attachment of GPI anchor to protein |
| BP | IMP | GO:0016255 | attachment of GPI anchor to protein |
| BP | TAS | GO:0016255 | attachment of GPI anchor to protein |
| BP | IBA | GO:0034394 | protein localization to cell surface |
| BP | IDA | GO:0046425 | regulation of JAK-STAT cascade |
Gene expression in normal tissue: PIGU
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIGU
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162791 | Attachment of GPI anchor to uPAR |
| reactome | R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 8 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIGU
CLASSFICATION
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