SLC45A2


Summary: This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 45 member 2MIM:606202Ensembl:ENSG00000164175HGNC:HGNC:16472PA1348977565p13.2

Gene Categories:

TRANSPORTER

GO terms in SLC45A2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0008506sucrose:proton symporter activity
CCIEAGO:0016021integral component of membrane
CCIEAGO:0033162melanosome membrane
BPIEAGO:0007601visual perception
BPISSGO:0015770sucrose transport
BPIEAGO:0042438melanin biosynthetic process
BPIEAGO:0048066developmental pigmentation
BPIEAGO:0050896response to stimulus

Gene expression in normal tissue: SLC45A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC45A2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-5662702Melanin biosynthesis
reactomeR-HSA-71291Metabolism of amino acids and derivatives
wikipathwaysWP3998Prader-Willi and Angelman Syndrome

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD77Itraconazole1
iGMDRD289Parthenolide7
iGMDRD192CIL561
iGMDRD103SN-385
iGMDRD158NSC1415404
iGMDRD137Indisulam2
iGMDRD202Curcumin3
iGMDRD147Prima-16
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD882CIL412
iGMDRD79Gemcitabine5
iGMDRD150RITA1
iGMDRD532Olaparib3
iGMDRD116CD4372
iGMDRD584VER 1550081
iGMDRD512nutlin 35
iGMDRD148Pifithrin-mu2
iGMDRD307Manumycin A5
iGMDRD123Isoevodiamine5
iGMDRD177Teniposide3
iGMDRD85Ursolic acid4
iGMDRD885Compound 1103
iGMDRD441TW 371
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD318PAC-12
iGMDRD30917AAG2
iGMDRD782DC-45-A23
iGMDRD8024-methylfasudil3
iGMDRD138PX 124
iGMDRD524ISX-93
iGMDRD690PRIMA-1MET3
iGMDRD506Fedratinib3
iGMDRD780PP-303
iGMDRD562Navitoclax3
iGMDRD399Selumetinib3
iGMDRD887Compound 23 citrate2
iGMDRD427ABT7372
iGMDRD144NSC953971
iGMDRD1008SR-II-138A3
iGMDRD772BRD47706
iGMDRD126Tipifarnib2
iGMDRD151CHM-11
iGMDRD297Austocystin D6
iGMDRD394BX-7952
iGMDRD201SKI II3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC45A2

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