SLC45A2
Summary: This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 45 member 2 | MIM:606202 | Ensembl:ENSG00000164175 | HGNC:HGNC:16472 | PA134897756 | 5p13.2 |
Gene Categories:
TRANSPORTERGO terms in SLC45A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0008506 | sucrose:proton symporter activity |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0033162 | melanosome membrane |
| BP | IEA | GO:0007601 | visual perception |
| BP | ISS | GO:0015770 | sucrose transport |
| BP | IEA | GO:0042438 | melanin biosynthetic process |
| BP | IEA | GO:0048066 | developmental pigmentation |
| BP | IEA | GO:0050896 | response to stimulus |
Gene expression in normal tissue: SLC45A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC45A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-5662702 | Melanin biosynthesis |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD289 | Parthenolide | 7 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD147 | Prima-1 | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD79 | Gemcitabine | 5 |
| iGMDRD150 | RITA | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD201 | SKI II | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC45A2
CLASSFICATION
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