HCK
Summary: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:142370 Ensembl IDEnsembl:ENSG00000101336 HGNC IDHGNC:HGNC:4840 PHARMGKB IDPA29216 Map Location20q11.21 | |||||
GO terms in HCK
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002522 | leukocyte migration involved in immune response |
| BP | TAS | GO:0002758 | innate immune response-activating signal transduction |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
Gene expression in normal tissue: HCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HCK
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | vifpathway | hiv-1 defeats host-mediated resistance by cem15 |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HCK
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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