HCK
Summary: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| HCK proto-oncogene, Src family tyrosine kinase | MIM:142370 | Ensembl:ENSG00000101336 | HGNC:HGNC:4840 | PA29216 | 20q11.21 |
GO terms in HCK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002522 | leukocyte migration involved in immune response |
| BP | TAS | GO:0002758 | innate immune response-activating signal transduction |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007498 | mesoderm development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030838 | positive regulation of actin filament polymerization |
| BP | TAS | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043299 | leukocyte degranulation |
| BP | IBA | GO:0045087 | innate immune response |
| BP | TAS | GO:0045728 | respiratory burst after phagocytosis |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
| BP | TAS | GO:0050727 | regulation of inflammatory response |
| BP | IMP | GO:0050764 | regulation of phagocytosis |
| BP | IMP | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IDA | GO:0071801 | regulation of podosome assembly |
| BP | IDA | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| BP | IMP | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005764 | lysosome |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005901 | caveola |
| CC | IMP | GO:0005925 | focal adhesion |
| CC | IEA | GO:0030133 | transport vesicle |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IMP | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IEA | GO:0042995 | cell projection |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: HCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HCK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | vifpathway | hiv-1 defeats host-mediated resistance by cem15 |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164944 | Nef and signal transduction |
| reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | glypican_1pathway | Glypican 1 network |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD885 | Compound 110 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HCK
CLASSFICATION
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