JUND
Summary: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| JunD proto-oncogene, AP-1 transcription factor subunit | MIM:165162 | Ensembl:ENSG00000130522 | HGNC:HGNC:6206 | PA30008 | 19p13.11 |
GO terms in JUND
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0002076 | osteoblast development |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IBA | GO:0009314 | response to radiation |
| BP | IEA | GO:0009416 | response to light stimulus |
| BP | IBA | GO:0009612 | response to mechanical stimulus |
| BP | IBA | GO:0010033 | response to organic substance |
| BP | IBA | GO:0010941 | regulation of cell death |
| BP | IBA | GO:0032496 | response to lipopolysaccharide |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0042493 | response to drug |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IBA | GO:0045597 | positive regulation of cell differentiation |
| BP | IEA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0051591 | response to cAMP |
| BP | IBA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| CC | TAS | GO:0000785 | chromatin |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0032993 | protein-DNA complex |
| CC | IDA | GO:0035976 | transcription factor AP-1 complex |
Gene expression in normal tissue: JUND
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JUND
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | fosbpathway | fosb gene expression and drug abuse |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP516 | Hypertrophy Model |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD286 | Nsc 632839 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JUND
CLASSFICATION
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