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JUND

Summary: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameJunD proto-oncogene, AP-1 transcription factor subunit OMIM IDMIM:165162 Ensembl IDEnsembl:ENSG00000130522 HGNC IDHGNC:HGNC:6206 PHARMGKB IDPA30008 Map Location19p13.11

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR DRUG RESISTANCE

GO terms in JUND

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

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Gene expression in normal tissue: JUND

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JUND

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Database	Pathway ID	Pathway Des.
biocarta	fosbpathway	fosb gene expression and drug abuse
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9018519	Estrogen-dependent gene expression
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	3
iGMDRD144	NSC95397	3
iGMDRD150	RITA	3
iGMDRD116	CD437	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JUND

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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