RGL4
Summary: This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ral guanine nucleotide dissociation stimulator like 4 | MIM:612214 | Ensembl:ENSG00000159496 | HGNC:HGNC:31911 | PA162401277 | 22q11.23 |
GO terms in RGL4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| MF | IEA | GO:0005085 | guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: RGL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD886 | Compound 1541A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RGL4
CLASSFICATION
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