RGL4


Summary: This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ral guanine nucleotide dissociation stimulator like 4MIM:612214Ensembl:ENSG00000159496HGNC:HGNC:31911PA16240127722q11.23

GO terms in RGL4


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0031410cytoplasmic vesicle
BPIEAGO:0007264small GTPase mediated signal transduction
MFIEAGO:0005085guanyl-nucleotide exchange factor activity

Gene expression in normal tissue: RGL4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RGL4


DatabasePathway IDPathway Des.
wikipathwaysWP455GPCRs, Class A Rhodopsin-like

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD772BRD47702
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 31
iGMDRD889Compound 7d-cis3
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus2
iGMDRD144NSC953971
iGMDRD150RITA1
iGMDRD314Tanespimycin1
iGMDRD341Triacsin c3
iGMDRD634SCHEMBL26080411
iGMDRD780PP-303
iGMDRD398Sepantronium2
iGMDRD506Fedratinib2
iGMDRD662JQ-12
iGMDRD887Compound 23 citrate1
iGMDRD872BRD71371
iGMDRD286Nsc 6328391
iGMDRD871BRD63681
iGMDRD188Piperlongumine3
iGMDRD147Prima-11
iGMDRD886Compound 1541A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RGL4

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