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MEN1

Summary: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemenin 1 OMIM IDMIM:613733 Ensembl IDEnsembl:ENSG00000133895 HGNC IDHGNC:HGNC:7010 PHARMGKB IDPA30746 Map Location11q13.1

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR KINASE CELL SURFACE HISTONE MODIFICATION DNA REPAIR SERINE THREONINE KINASE RNA DIRECTED DNA POLYMERASE

GO terms in MEN1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0000165	MAPK cascade
BP	IEA	GO:0000278	mitotic cell cycle
BP	IDA	GO:0001933	negative regulation of protein phosphorylation
BP	IGI	GO:0002076	osteoblast development
BP	IEA	GO:0003309	type B pancreatic cell differentiation

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Gene expression in normal tissue: MEN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MEN1

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Database	Pathway ID	Pathway Des.
wikipathways	WP179	Cell Cycle
kegg	hsa04934	Cushing,s syndrome - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-170834	Signaling by TGF-beta Receptor Complex
reactome	R-HSA-194315	Signaling by Rho GTPases

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD23	Gossypol	3
iGMDRD64	Parbendazole	6
iGMDRD246	NPC26	1
iGMDRD506	Fedratinib	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MEN1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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