MEN1


Summary: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
menin 1MIM:613733Ensembl:ENSG00000133895HGNC:HGNC:7010PA3074611q13.1

GO terms in MEN1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000165MAPK cascade
BPIEAGO:0000278mitotic cell cycle
BPIDAGO:0001933negative regulation of protein phosphorylation
BPIGIGO:0002076osteoblast development
BPIEAGO:0003309type B pancreatic cell differentiation
BPNASGO:0006281DNA repair
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007420brain development
BPIBAGO:0008285negative regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0009411response to UV
BPIDAGO:0010332response to gamma radiation
BPIEAGO:0010812negative regulation of cell-substrate adhesion
BPIMPGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0032092positive regulation of protein binding
BPIEAGO:0032925regulation of activin receptor signaling pathway
BPIEAGO:0034968histone lysine methylation
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIGIGO:0045668negative regulation of osteoblast differentiation
BPIMPGO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0045786negative regulation of cell cycle
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046329negative regulation of JNK cascade
BPIEAGO:0046697decidualization
BPIEAGO:0050680negative regulation of epithelial cell proliferation
BPIMPGO:0051974negative regulation of telomerase activity
BPIEAGO:0061469regulation of type B pancreatic cell proliferation
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0071375cellular response to peptide hormone stimulus
BPIEAGO:0071559response to transforming growth factor beta
BPIEAGO:1902807negative regulation of cell cycle G1/S phase transition
BPTASGO:1904837beta-catenin-TCF complex assembly
CCISSGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0000785chromatin
CCIDAGO:0000785chromatin
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005788endoplasmic reticulum lumen
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016363nuclear matrix
CCIDAGO:0032154cleavage furrow
CCIDAGO:0032991protein-containing complex
CCIBAGO:0035097histone methyltransferase complex
CCIDAGO:0035097histone methyltransferase complex
CCIPIGO:0035097histone methyltransferase complex
MFIDAGO:0000400four-way junction DNA binding
MFIBAGO:0000403Y-form DNA binding
MFIDAGO:0000403Y-form DNA binding
MFIBAGO:0003682chromatin binding
MFIBAGO:0003690double-stranded DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0018024histone-lysine N-methyltransferase activity
MFIDAGO:0018024histone-lysine N-methyltransferase activity
MFIDAGO:0030674protein binding, bridging
MFIBAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0070412R-SMAD binding

Gene expression in normal tissue: MEN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MEN1


DatabasePathway IDPathway Des.
wikipathwaysWP179Cell Cycle
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5626467RHO GTPases activate IQGAPs
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8957275Post-translational protein phosphorylation
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD23Gossypol3
iGMDRD64Parbendazole6
iGMDRD246NPC261
iGMDRD506Fedratinib3
iGMDRD329Merck605
iGMDRD562Navitoclax3
iGMDRD286Nsc 6328391
iGMDRD414MST-3123
iGMDRD231Importazole3
iGMDRD434BMS-5369246
iGMDRD158NSC1415403
iGMDRD138PX 123
iGMDRD123Isoevodiamine3
iGMDRD679Bistramide A3
iGMDRD466Chaetocin3
iGMDRD177Teniposide3
iGMDRD61Kinetin riboside3
iGMDRD237ABT-7513
iGMDRD193Fqi13
iGMDRD71Sparfosic acid3
iGMDRD79Gemcitabine2
iGMDRD560MK-22064
iGMDRD150RITA6
iGMDRD427ABT7373
iGMDRD779PRL-3 Inhibitor I3
iGMDRD670ML 2103
iGMDRD229B023
iGMDRD599Salermide3
iGMDRD126Tipifarnib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MEN1

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