MEN1
Summary: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| menin 1 | MIM:613733 | Ensembl:ENSG00000133895 | HGNC:HGNC:7010 | PA30746 | 11q13.1 |
GO terms in MEN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IGI | GO:0002076 | osteoblast development |
| BP | IEA | GO:0003309 | type B pancreatic cell differentiation |
| BP | NAS | GO:0006281 | DNA repair |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007420 | brain development |
| BP | IBA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0009411 | response to UV |
| BP | IDA | GO:0010332 | response to gamma radiation |
| BP | IEA | GO:0010812 | negative regulation of cell-substrate adhesion |
| BP | IMP | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0032925 | regulation of activin receptor signaling pathway |
| BP | IEA | GO:0034968 | histone lysine methylation |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IGI | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IMP | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046329 | negative regulation of JNK cascade |
| BP | IEA | GO:0046697 | decidualization |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IMP | GO:0051974 | negative regulation of telomerase activity |
| BP | IEA | GO:0061469 | regulation of type B pancreatic cell proliferation |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071375 | cellular response to peptide hormone stimulus |
| BP | IEA | GO:0071559 | response to transforming growth factor beta |
| BP | IEA | GO:1902807 | negative regulation of cell cycle G1/S phase transition |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| CC | ISS | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0000785 | chromatin |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:0035097 | histone methyltransferase complex |
| CC | IPI | GO:0035097 | histone methyltransferase complex |
| MF | IDA | GO:0000400 | four-way junction DNA binding |
| MF | IBA | GO:0000403 | Y-form DNA binding |
| MF | IDA | GO:0000403 | Y-form DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IDA | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IDA | GO:0030674 | protein binding, bridging |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IPI | GO:0070412 | R-SMAD binding |
Gene expression in normal tissue: MEN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MEN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD23 | Gossypol | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD150 | RITA | 6 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD229 | B02 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MEN1
CLASSFICATION
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